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gyrase

   Also found in: Wikipedia 0.07 sec.
gyrase
[jī′rās]
an enzyme that promotes the unwinding of the closed circular deoxyribonucleic acid helix of bacteria.

gyrase
one of the type II topoisomerases involved in the supercoiling of double-stranded circular DNA molecules.


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Development of resistance to fluoroquinolones is a stepwise process, involving spontaneous mutations in the genes encoding the target enzymes DNA gyrase and the topoisomerase IV.
Resistance requires only a single mutation in the code for DNA gyrase.
Susceptibility of Campylobacter species to nalidixic-acid, enoxacin, and other DNA gyrase inhibitors.
 
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