GUCY2C

(redirected from Guanylyl cyclase c)
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GUCY2C

A gene on chromosome 12p12 that encodes guanylate cyclase 2C, a receptor for E coli heat-stable enterotoxin. It is also activated by the endogenous peptide guanylin.
References in periodicals archive ?
Its lead drug candidate is SP-304 (Guanilib), a guanylyl cyclase C (GC-C) receptor agonist, to treat gastrointestinal disorders, primarily chronic constipation and constipation-predominant irritable bowel syndrome (IBS-C).
The research will include studies to encourage participation in cancer vaccine trials and a clinical trial to evaluate the safety and effect on the immune system of a guanylyl cyclase C (GCC)-based vaccine for treating colon cancer patients.
301, #7, this week published positive results from a major prospective 5-year multicenter study of over 400 enrolled patients demonstrating that guanylyl cyclase C (GCC) is the strongest independent predictor of colorectal cancer recurrence in patients considered low risk by current assessment methods.
In comparison, recent studies demonstrated that guanylyl cyclase C (GCC) was a specific marker for metastatic colorectal cancer.
The company says that GCC-B1 can find one cancer cell in 10,000,000 normal cells by detecting the presence of guanylyl cyclase C (GC-C), which is found on metastatic colorectal cancer cells.