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guanylate cyclase |
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guanylate cyclase enzyme catalyzing the synthesis of 3′5′ cyclic-GMP from GTP in photoreceptor cells of the retina in its dark state. cGMP binds to Na+-channels of the retinal cells, causing them to open. |
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Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one. The paper elucidates the means by which nitric oxide and carbon monoxide bind to a protein called soluble guanylyl cyclase (sGC) which is critical in the formation of another protein, cGMP, which induces the relaxation of blood vessels. Nitric oxide is a biogenic messenger, an EDRF (15,16), and it activates the guanylyl cyclase system (17) [it converts guanosine triphosphate to cyclic guanosine monophosphate (cGMP)], raising the cGMP pool and therefore inducing, among other things, vasodilatation (17) by lowering the intracellular calcium ion (16). |
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