amyotrophic lateral sclerosis-parkinsonism/dementia complex type 1

(redirected from Guam disease)

amyotrophic lateral sclerosis-parkinsonism/dementia complex type 1

A neurodegenerative disorder (OMIM:105500) characterised by chronic, progressive and uniformly fatal amyotrophic lateral sclerosis and parkinsonism-dementia. Both diseases are known to occur in the same kindred, the same sibship, and even the same individual.

Molecular pathology
Defects of TRPM7 have been linked to amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam.
References in periodicals archive ?
He's the scientist who first proposed a role for BMAA in the Guam disease.
In the Guam disease, people typically lose muscle strength and control and then waste away.
Early investigators of the Guam disease ruled out genetic explanations and found links to traditional lifestyles.

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