GHR

(redirected from Growth hormone receptor)
Also found in: Acronyms, Wikipedia.

GHR

A gene on chromosome 5p13-p12 that encodes growth hormone receptor, a type-I cytokine receptor which, once GH is bound, dimerizes and activates the JAK2/STAT5 transduction pathway, leading to growth.

Molecular pathology
Defects in GHR cause Laron type dwarfism.
Mentioned in ?
References in periodicals archive ?
Gray et al [56] studied the roles of growth hormone, hepatic growth hormone receptors and insulin-like growth factor-I in growth regulation in the gobiid teleost, Gillichthys mirabilis.
GROWTH HORMONE RECEPTOR (GHR) AND ITS INTRACELLULAR SIGNALING
Developmental expression of hepatic growth hormone receptor and insulin-like growth factor-I mRNA in the chicken.
Therefore, the present study is aimed to elucidate the mechanisms underlying the action of CLA on fat deposition through examination of the hormones which are related with fat metabolism and mainly secreted by adipose tissue, and on the target gene of growth hormone (GH) including growth hormone receptor (cGHR), insulin-like growth factor-1 (cIGF-1) and its I receptor (cIGF-IR) in abdominal fat, and cPPAR[gamma], cAdiponectin and its I receptor (cAdipoIR) in abdominal fat of broiler chickens.
Not only is there a clear medical need for a growth hormone receptor antagonist with improved half-life, but this program initiates the application of DiAthegen's technology to an array of protein therapeutics in the growth hormone and diabetes area that will benefit from extended pharmacokinetics.
The growth hormone receptor and growth hormone-binding protein:structure, functions, and regulation.
Primary IGFD is typically caused by abnormalities of either the growth hormone receptor or growth hormone signaling pathway.
Melbourne biotech company Antisense Therapeutics, has developed a drug called ATL1103, designed to block Growth Hormone receptor (GHr) expression.
SOMAVERT is the first in a new class of medicines called growth hormone receptor antagonists and the only medicine designed to specifically block the effects of excess growth hormone in acromegaly.

Full browser ?