GHR

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GHR

A gene on chromosome 5p13-p12 that encodes growth hormone receptor, a type-I cytokine receptor which, once GH is bound, dimerizes and activates the JAK2/STAT5 transduction pathway, leading to growth.

Molecular pathology
Defects in GHR cause Laron type dwarfism.

References in periodicals archive ?

Nutritional regulation of growth hormone receptor gene expression.

Effects of dietary restriction on the expression of lipid metabolism and growth hormone signaling genes in the longissimus dorsi muscle of Korean cattle steers

Gray et al [56] studied the roles of growth hormone, hepatic growth hormone receptors and insulin-like growth factor-I in growth regulation in the gobiid teleost, Gillichthys mirabilis.

A review on the physiology of Insulin like Growth Factor-I (IGF-I) peptide in bony fishes and its phylogenetic correlation in 30 different taxa of 14 families of teleosts

A common polymorphism of the growth hormone receptor is associated with increased responsiveness to growth hormone.

Growth hormone (GH) receptor isoform in acromegaly: lower concentrations of GH but not insulin-like growth factor-I in patients with a genomic deletion of exon 3 in the GH receptor gene

Determination of B-32 binding to growth hormone receptor

Development and characterization of a novel anti-idiotypic monoclonal antibody to growth hormone, which can mimic physiological functions of growth hormone in primary porcine hepatocytes

GROWTH HORMONE RECEPTOR (GHR) AND ITS INTRACELLULAR SIGNALING

Modulation of the somatotropic axis in periparturient dairy cows

Developmental expression of hepatic growth hormone receptor and insulin-like growth factor-I mRNA in the chicken.

The endocrine regulation of chicken growth

Therefore, the present study is aimed to elucidate the mechanisms underlying the action of CLA on fat deposition through examination of the hormones which are related with fat metabolism and mainly secreted by adipose tissue, and on the target gene of growth hormone (GH) including growth hormone receptor (cGHR), insulin-like growth factor-1 (cIGF-1) and its I receptor (cIGF-IR) in abdominal fat, and cPPAR[gamma], cAdiponectin and its I receptor (cAdipoIR) in abdominal fat of broiler chickens.

Effect of dietary conjugated linoleic acid (CLA) on abdominal fat deposition in yellow-feather broiler chickens and its possible mechanism

Not only is there a clear medical need for a growth hormone receptor antagonist with improved half-life, but this program initiates the application of DiAthegen's technology to an array of protein therapeutics in the growth hormone and diabetes area that will benefit from extended pharmacokinetics.

Phyton Biotech, Inc., a DFB Pharmaceuticals Affiliate, Signs Licensing Agreement With DiAthegen LLC to Commercialize Growth Hormone Receptor Antagonist That Treats Acromegaly, Cancer, Diabetes

The growth hormone receptor and growth hormone-binding protein:structure, functions, and regulation.

Growth hormone signaling in the regulation of acid labile subunit

Primary IGFD is typically caused by abnormalities of either the growth hormone receptor or growth hormone signaling pathway.

Tercica Initiates Phase IIIb Clinical Trial of RhIGF-1 in Short Stature Caused by Primary IGF-1 Deficiency

Melbourne biotech company Antisense Therapeutics, has developed a drug called ATL1103, designed to block Growth Hormone receptor (GHr) expression.

New Drug Offers Hope for People With Two of the Most Common and Debilitating Eye Diseases; Results from Research in Victoria, Australia Give New Hope to People Suffering from Diseases that Are Major Causes of Blindness

SOMAVERT is the first in a new class of medicines called growth hormone receptor antagonists and the only medicine designed to specifically block the effects of excess growth hormone in acromegaly.

U.S. Food and Drug Administration Approves SOMAVERT(R) for the Treatment Of Acromegaly; First in a New Class of Medicines Treats Debilitating Hormone Disease