GHR

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GHR

A gene on chromosome 5p13-p12 that encodes growth hormone receptor, a type-I cytokine receptor which, once GH is bound, dimerizes and activates the JAK2/STAT5 transduction pathway, leading to growth.

Molecular pathology
Defects in GHR cause Laron type dwarfism.

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References in periodicals archive ?

growth hormone (gh), growth hormone receptor (ghr), insulin-like growth factor 1 (igf-1), insulin-like growth factor receptor (igf-1r), insulin-like growth factor binding protein 1 (igfbp-1), ghrelin (ghrl), cholecystokinin (cck) and glucokinase (gck), thyroglobulin (tg).

Comparison of gene expression patterns of key growth genes between different rate growths in zebrafish (Danio rerio) siblings

Differential intracellular signalling properties of the growth hormone receptor induced by the activation of an anti-GHR antibody.

Preparation and characterization of an antibody antagonist that targets the porcine growth hormone receptor

Gender-specific expression of multiple estrogen receptors, growth hormone receptors, insulin-like growth factors and vitellogenins, and effects of 17 beta-estradiol in the male tilapia (Oreochromis mossambicus).

A review on the physiology of Insulin like Growth Factor-I (IGF-I) peptide in bony fishes and its phylogenetic correlation in 30 different taxa of 14 families of teleosts

Growth hormone receptor gene expression in porcine skeletal and cardiac muscles is selectively regulated by postnatal undernutrition.

Effects of dietary restriction on the expression of lipid metabolism and growth hormone signaling genes in the longissimus dorsi muscle of Korean cattle steers

Determination of B-32 binding to growth hormone receptor

Development and characterization of a novel anti-idiotypic monoclonal antibody to growth hormone, which can mimic physiological functions of growth hormone in primary porcine hepatocytes

GROWTH HORMONE RECEPTOR (GHR) AND ITS INTRACELLULAR SIGNALING

Modulation of the somatotropic axis in periparturient dairy cows

Developmental expression of hepatic growth hormone receptor and insulin-like growth factor-I mRNA in the chicken.

The endocrine regulation of chicken growth

Therefore, the present study is aimed to elucidate the mechanisms underlying the action of CLA on fat deposition through examination of the hormones which are related with fat metabolism and mainly secreted by adipose tissue, and on the target gene of growth hormone (GH) including growth hormone receptor (cGHR), insulin-like growth factor-1 (cIGF-1) and its I receptor (cIGF-IR) in abdominal fat, and cPPAR[gamma], cAdiponectin and its I receptor (cAdipoIR) in abdominal fat of broiler chickens.

Effect of dietary conjugated linoleic acid (CLA) on abdominal fat deposition in yellow-feather broiler chickens and its possible mechanism

The growth hormone-binding protein in rat serum is an alternatively spliced form of the rat growth hormone receptor.

Growth hormone signaling in the regulation of acid labile subunit

As Executive Vice President of Sensus, a biotech company founded in Austin and subsequently acquired by Pharmacia (Pfizer), Davis was instrumental in the successful registration of Somavert(R), a growth hormone receptor antagonist, in the US, Europe and Japan.

ResearchPoint Adds Key Executive

That market is currently dominated by once-a-month Sandostatin LAR(R) Depot (octreotide acetate for injectable suspension) from Novartis (NYSE: NVS) and includes daily injections of Somavert (pegvisomant for injection), a growth hormone receptor antagonist, from Pfizer (NYSE: PFE).

Valera Pharmaceuticals Completes Enrollment for a Phase II Study of a Long-Duration Implant to Treat Acromegaly, a Growth Disorder Most Prevalent Among Middle Aged Adults

SOMAVERT is the first in a new class of medicines called growth hormone receptor antagonists.

Inhale Technology Used in Newly-Approved Product in Europe; European Commission Approves SOMAVERT for the Treatment of Acromegaly