Grignard reaction


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Grignard reaction

(grē-nyar′) [François AugusteVictor Grignard, French chemist and Nobel laureate, 1871–1935]
A classical organic-chemical process that forms carbon-carbon bonds. It is used to build carbon chains in compounds including drugs, food additives, toxins, and pesticides.
References in periodicals archive ?
Until recently, only a few kinetic studies of the Grignard reaction with silanes have been published [2-4].
Noteworthy are (a) the unusual structural features of ND354, (b) the use of a Grignard reaction of a lactam in its synthesis; (c) cholesterol inhibition by action at the lanosterol stage without a build up of sterol precursors and (d) absence of adverse side effects in animal or human studies.
We synthesized Tris-OH by adding 4-chlorobromobenzene to 4,4'-dichlorobenzophenone by a Grignard reaction.