Grignard reaction


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Grignard reaction

(grē-nyar′) [François AugusteVictor Grignard, French chemist and Nobel laureate, 1871–1935]
A classical organic-chemical process that forms carbon-carbon bonds. It is used to build carbon chains in compounds including drugs, food additives, toxins, and pesticides.
References in periodicals archive ?
In conclusion, we have elaborated an experimental method for determination of rate and equilibrium constants for the Grignard reaction with alkoxysilanes.
Noteworthy are (a) the unusual structural features of ND354, (b) the use of a Grignard reaction of a lactam in its synthesis; (c) cholesterol inhibition by action at the lanosterol stage without a build up of sterol precursors and (d) absence of adverse side effects in animal or human studies.
We synthesized Tris-OH by adding 4-chlorobromobenzene to 4,4'-dichlorobenzophenone by a Grignard reaction.