Grignard reaction

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Grignard reaction

(grē-nyar′) [François AugusteVictor Grignard, French chemist and Nobel laureate, 1871–1935]
A classical organic-chemical process that forms carbon-carbon bonds. It is used to build carbon chains in compounds including drugs, food additives, toxins, and pesticides.
References in periodicals archive ?
In 2008-2009, member Christopher Grignard was a doctoral student when Yvonne Johnson was brought into a University of Alberta classroom as a guest speaker.
Substitution of the fluorine atoms bonded to the boron center in 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (F-BODIPY) compounds with ethynyl or aryl linkages can be achieved through either Grignard or lithium organometallic reagents.
Among the topics are solid-phase reactions of polymer-bound arenesulfonates with aryl Grignard reagents, resin-to-resin transfer reactions through Sonogashira coupling, polyaniline-immobilized palladium for Suzuki-Miyuaura coupling reactions in water, solid-phase reactions of resin-supported boronic acids, and the palladium-catalyzed solid-phase synthesis of allelic amines.
Among these reactions are an electrophilic aromatic substitution, a Williamson ether synthesis, a Grignard coupling reaction and a Hell-Volhard-Zelinski reaction.
This represents an improvement on the well-established Grignard method for diaklylations of esters using metallic magnesium and alkyl halides.
Poly(silyleneethynylenephenyleneethynylene)s (PHSEPE, PMSEPE, and PVSEPE) were synthesized by Grignard method from dichlorosilane and diethynylbenzene with the same molar ratios of 2:3.
Hyde picked up Professor Kipping's work on silicones and soon he was preparing lab size quantities of silicone polymers using the Grignard route, which Kipping pioneered.
The bespoke French race car, chasis number 11006, was delivered new to Georges Grignard who campaigned it for two years - even winning the 1950 Grand Prix de Paris - and then, after buying another Talbot-Lago, sold it to Roger Laurent, Jacques Swaters and Charles de Tornaco - three amateur Belgian drivers who dreamed of an all-Belgian racing team.
The modified thiophene monomer is polymerized by a Grignard metathesis reagent to form a polythiophene living intermediate, which reacts with a second thiophene monomer to form an AB block copolymer.
Alain Grignard, commander of Belgium's anti-terrorism police unit, says: "The intermingling of terrorist networks with the criminal milieu is becoming more and more important.