gray syndrome

(redirected from Grey Infant Syndrome)

gray syndrome

 [gra]
a potentially fatal condition seen in neonates, particularly premature infants, due to a reaction to chloramphenicol, characterized by an ashen gray cyanosis, listlessness, weakness, and hypotension. Called also gray baby syndrome.

gray syn·drome

, gray baby syndrome
gray appearance of an infant at birth and during the neonatal period that can be caused by transplacental toxic effects of the drug chloramphenicol taken by the mother during late pregnancy; the syndrome may be fatal.

gray syndrome

a toxic condition in neonates, especially premature infants, caused by a reaction to chloramphenicol. Because the body's mechanisms for detoxification and excretion of drugs are immature, the infant has limited ability to conjugate and thus eliminate the chloramphenicol. The condition is named for the characteristic ashen-gray cyanosis, which is accompanied by abdominal distension, hypothermia, vomiting, respiratory distress, and vascular collapse. The syndrome, which is fatal if the drug is continued, can be prevented by conservative dosages of the drug and by restriction of its use in women during late pregnancy or labor (because chloramphenicol readily crosses the placental barrier) and in lactating mothers. Also called gray baby syndrome.
A condition that may occur when chloramphenicol levels exceed 70 µg/mL; premature infants are most susceptible, given their limited capacity to glucuronidate and excrete chloramphenicol, the functional deficiency in glucuronyl transferase activity corrects itself within the first 3–4 wks of life; high levels of chloramphenicol inhibit mitochondrial electron transport, disrupting energy metabolism; in children < 1 month of age, doses should be 25 mg/kg
Lab Clourimetry, GLC, HPLC, microbiologic, radioenzymatic methods

gray syn·drome

, gray baby syndrome (grā sin'drōm, bā'bē)
Ashen appearance of an infant at birth and during the neonatal period that can be caused by transplacental toxic effects of the drug chloramphenicol taken by the mother during late pregnancy; the syndrome may be fatal.