Greenfield's disease


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Greenfield's disease

 [grēn´fēldz]
the infantile form of metachromatic leukodystrophy.

Greenfield's disease

Etymology: Joseph G. Greenfield, British pathologist, 1884-1958
a disorder of the white matter of the brain tissue, characterized by an accumulation of sphingolipid in both parenchymal and supportive tissues and a diffuse loss of myelination. An infantile form usually begins by the third year of life, with symptoms that include loss of vision, rigidity, motor disorders, and mental deterioration. A juvenile form usually begins before 10 years of age and an adult form after 16 years of age; the adult form is marked by psychiatric symptoms that progress to dementia. See also leukodystrophy.