AKAP12

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AKAP12

A gene on chromosome 6q24-q25 that encodes a member of the structurally diverse A-kinase anchor protein (AKAP) family, which binds to the regulatory subunits (RI/RII) of protein kinase A (PKA), confining PKA to discrete locations within the cell based on different targeting motifs. AKAP12 is expressed in endothelial cells, fibroblasts and osteosarcoma cells, associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction.

Molecular pathology
AKAP12 antibodies may be produced in myasthenia gravis.
References in periodicals archive ?
For Davis Mills, the Texas billionaire and the mogul at the head of Gravin Oil, the game is all about winning.
Gravin & co-authors in 1983 reported 70% diffuse and 29% of follicular type.
ICE manager Gravin Mayorga said the 11 projects will be built to sell power to the ICE, and supply electricity to 225,000 households.
Clinton: Andrea Charette, Sarah Elizabeth Freel, Gravin E.
Alli mismo refiere la definicion de Chapman & Gravin (1993): "un estado afectivo, cognitivo y negativo complejo caracterizado por la sensacion que experimenta la persona de encontrarse amenazada en su integridad, por su sentimiento de impotencia para hacer frente a esta amenaza y por el agotamiento de los recursos personales y psicosociales que le permitirian afrontarla".
This pattern has been regularly found in tropical forest and has been suggested as a key factor for the co-existence of tree species, leading to high diversity in this environment (Janzen, 1970; Connell, 1971; Gravin and Peart, 1997).
Die oprigting in 1891 van die Battswood-insteHings--die oefenskool, sekondere skool en onderwyskollege - is moontlik gemaak deur die gravin van Stamford met haar skenking van grond en geld.
The rally also included Gandhian follower, Gravin Brown from Australia who walked with the school children.
On this point we agree with the definition of suffering given by Chapman and Gravin (1993): an 'emotional, cognitive, complex and negative condition characterized by the person's feelings on finding his or her integrity threatened, by a feeling of powerlessness to face this threat, and by the exhaustion of those individual and psychosocial resources that would allow him or her to cope with the threat'.
El sufrimiento ha sido un tema muy investigado en los ultimos anos en la literatura medica y psicologica, especialmente en cuanto a su diferenciacion del dolor y la busqueda de instrumentos para su evaluacion (Bayes, 1998, 2000, 2001, 2002; Callahan, 2000; Cassell, 1982; Chapman y Gravin, 1993; Lain-Entralgo, 1968; Loeser y Melzack, 1999).
Mas adelante, Chapman y Gravin (8) retoman lo desarrollado por Cassell y amplian la definicion del sufrimiento considerandolo "un estado afectivo, cognitivo y negativo, que se acompana de una sensacion de amenaza a la integridad, de un sentimiento de impotencia y del agotamiento de recursos para afrontar dicha amenaza".