AKAP12

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AKAP12

A gene on chromosome 6q24-q25 that encodes a member of the structurally diverse A-kinase anchor protein (AKAP) family, which binds to the regulatory subunits (RI/RII) of protein kinase A (PKA), confining PKA to discrete locations within the cell based on different targeting motifs. AKAP12 is expressed in endothelial cells, fibroblasts and osteosarcoma cells, associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction.

Molecular pathology
AKAP12 antibodies may be produced in myasthenia gravis.
References in periodicals archive ?
ICE manager Gravin Mayorga said the 11 projects will be built to sell power to the ICE, and supply electricity to 225,000 households.
Clinton: Andrea Charette, Sarah Elizabeth Freel, Gravin E.
Die oprigting in 1891 van die Battswood-insteHings--die oefenskool, sekondere skool en onderwyskollege - is moontlik gemaak deur die gravin van Stamford met haar skenking van grond en geld.
The rally also included Gandhian follower, Gravin Brown from Australia who walked with the school children.
De soap duurde een aantal weken, totdat drie dagen geleden in een Brusselse gravin dan toch een potentiele geldschieter werd gevonden.
Benito is joined at Greater Bay Bank's Santa Clara Valley Commercial Banking Group by Bruce Vanderberg, senior vice president, Margo Gravin, senior vice president, Chad Stearns, vice president and Ryan Connelly, relationship manager.
Gravin Mayorga, manager of the Institute, said works include electromechanical improvements and work on the turbines.
Vir die leser wat 'n spesifiek Afrikaanse verbintenis met die teks soek, mag twee feite ter sake wees: dat die subjek, gravin Martha, 'n half-geletterde Afrikaanssprekende (miskien meer korrek: Kaaps-Hollandssprekende) vrou was en dat die digter S.
It was led by its patron, Gravin Brown, an octogenarian Gandhian from Australia.