Graves' ophthalmopathy


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Graves' ophthalmopathy

Endocrinology A potentially disfiguring, sight-threatening condition that occurs in 25-50% of Pts with Graves' disease Clinical Gritty sensation in the eyes, diploplia, blurred vision, ↑ lacrimation, exophthalmos, extraocular muscle dysfunction, periorbital edema, lid edema, retraction, conjunctival chemosis and injection, exposure-type keratitis, photophobia. See Graves' disease.

Graves' ophthalmopathy

A severe eye disorder associated with thyroid gland dysfunction affecting mainly women in their 30s and 40s. It is an autoimmune disorder involving a massive cellular and fluid infiltration of the soft tissues of the bony orbit so that the upper eyelids are retracted, the eyeballs protuberant, eye movement limited and parts of the corneas often exposed and liable to drying. Optic nerve compression may lead to visual loss. Surgical decompression of the orbit may be necessary. See also EXOPHTHALMOS and THYROTOXICOSIS.
References in periodicals archive ?
Our results were in agreement with Vestergaard20 as he reported that GD patients who smoke had a 5 times higher threat of developing Graves' ophthalmopathy than those who do not smoke.
Graves' ophthalmopathy usually presents as bilateral, symmetrical enlargement of the extraocular muscles associated with increase in retrobulbar fat volume.
Prednisone and cyclosporine in the treatment of severe Graves' ophthalmopathy.
Frontoethmoid mucocele complicating Graves' ophthalmopathy.
Relationship between disease duration and predominant orbital T cell subset in Graves' ophthalmopathy.
Global Markets Direct's, 'Graves' Ophthalmopathy - Pipeline Review, H1 2016', provides an overview of the Graves' Ophthalmopathy pipeline landscape.
In addition, up to 40 percent of GD patients exhibit a condition called Graves' ophthalmopathy (GO), also known as thyroid associated orbitopathy (TAO).
entitled "Cigarette Smoke Extract-Induced Oxidative Stress and Fibrosis-Related Genes Expression in Orbital Fibroblasts from Patients with Graves' Ophthalmopathy," the authors evaluated some clues for the impact of cigarette smoking on Graves' ophthalmopathy and offered a theoretical basis for the potential and rational use of antioxidants in treating Graves' ophthalmopathy.
Removing the thyroid gland to correct the hormone imbalance does not correct Graves' ophthalmopathy or myxedema.
Graves' ophthalmopathy and thyroid eye disease are terms that are often used interchangeably in the literature, as ocular manifestations of thyroid disease are mostly associated with Graves' disease.
There were no symptoms or signs of Graves' ophthalmopathy.