Graves' ophthalmopathy

Graves' ophthalmopathy

Endocrinology A potentially disfiguring, sight-threatening condition that occurs in 25-50% of Pts with Graves' disease Clinical Gritty sensation in the eyes, diploplia, blurred vision, ↑ lacrimation, exophthalmos, extraocular muscle dysfunction, periorbital edema, lid edema, retraction, conjunctival chemosis and injection, exposure-type keratitis, photophobia. See Graves' disease.

Graves' ophthalmopathy

A severe eye disorder associated with thyroid gland dysfunction affecting mainly women in their 30s and 40s. It is an autoimmune disorder involving a massive cellular and fluid infiltration of the soft tissues of the bony orbit so that the upper eyelids are retracted, the eyeballs protuberant, eye movement limited and parts of the corneas often exposed and liable to drying. Optic nerve compression may lead to visual loss. Surgical decompression of the orbit may be necessary. See also EXOPHTHALMOS and THYROTOXICOSIS.
References in periodicals archive ?
Graves' ophthalmopathy and thyroid eye disease are terms that are often used interchangeably in the literature, as ocular manifestations of thyroid disease are mostly associated with Graves' disease.
There were no symptoms or signs of Graves' ophthalmopathy.
Inter-method variability in TSH-receptor antibody measurement: implication for the diagnosis of Graves' disease and for the follow-up of Graves' ophthalmopathy.
Thyroid hemiagenesis with Graves' disease, Graves' ophthalmopathy and multinodular goiter.
131]I administration may lead to a medical crises called thyroid storm with excess release of preformed hormones into circulation and (iv) patients with Graves' ophthalmopathy.
The newly discovered compound, which is a receptor antagonist, may have the added benefit of helping those with eye problems caused by Graves' disease - called Graves' ophthalmopathy - experienced by more than 25 percent of people with the disease.
Graves' ophthalmopathy (GO) is an inflammatory process that affects tissues of the orbit in patients with Graves' disease (GD) and, more rarely, with Hashimoto's thyroiditis.
Several reports have indicated that tobacco use is a risk factor for Graves' ophthalmopathy," noted Dr.
Gerding MN, van der Meer JW, Broenink M, et al: Association of thyrotropin receptor antibodies with the clinical features of Graves' ophthalmopathy.
Graves' ophthalmopathy (also known as thyroid eye disease [TED], dysthyroid/thyroid-associated orbitopathy [TAO], Graves' orbitopathy) is an autoimmune inflammatory disorder affecting the orbit around the eye, characterized by upper eyelid retraction, swelling (edema), redness (erythema), conjunctivitis, and bulging eyes (proptosis).
Graves' ophthalmopathy following external neck irradiation for nonthyroidal neoplastic disease.
Early effects of methylprednisolone infusion on cystatin C in patients with severe Graves' ophthalmopathy.