Graves' disease


Also found in: Dictionary, Thesaurus, Legal, Acronyms, Encyclopedia, Wikipedia.

Graves' disease

(grāvz)
n.
A condition usually caused by excessive production of thyroid hormone and characterized by an enlarged thyroid gland, protrusion of the eyeballs, a rapid heartbeat, and nervous excitability. Also called exophthalmic goiter.

Graves' disease

[grāvz]
Etymology: Robert J. Graves, Irish physician, 1796-1853
a multisystem autoimmune disorder characterized by pronounced hyperthyroidism, usually associated with an enlarged thyroid gland and exophthalmos (abnormal protrusion of the eyeball). The origin is unknown, but the disease is familial and is usually associated with thyroid-stimulating autoantibodies that bind to TSH receptors and stimulate thyroid secretion. The disease, which is five times more common in women than in men, occurs most frequently when the individual is between 30 and 60 years of age and can arise after an infection or physical or emotional stress. Typical signs, which are related to hyperthyroidism, are nervousness, a fine tremor of the hands, weight loss, fatigue, breathlessness, palpitations, increased heat intolerance, increased metabolic rate, and GI motility. An enlarged thymus, generalized hyperplasia of the lymph nodes, blurred or double vision, localized myxedema, atrial arrhythmias, and osteoporosis may occur. The diagnosis may be established by tests that measure TSH, thyroxine, and triiodothyronine levels in serum. If necessary, radioactive iodine uptake in the gland is tested. Treatment may include prescription of antithyroid drugs, such as methimazole, propylthiouracil, and iodine preparations. Radioactive iodine may be administered, but hospitalization for a few days is recommended for patients treated with a large dose. Occasionally subtotal thyroidectomy may be indicated. In patients with inadequately controlled disease, infection or stress may precipitate a life-threatening thyroid storm. The exophthalmia may or may not resolve with the treatment of the disease. Also called exophthalmic goiter, thyrotoxicosis, toxic goiter.

Graves' disease

Basedow disease Endocrinology The most common cause of hyperthyroidism, due to excess thyroid stimulation by autoantibodies with diffuse toxic goiter Clinical Hyperthyroidism, exophthalmos, dermatopathy–painless, reddish lumpy rash on anterior leg, familial tendency, tachycardia, ↑ metabolic rate Risk factors Stress, smoking, RT to neck, medications–eg IL-2 and IFN-alpha, and viral infection Diagnosis Thyroid scan–diffuse ↑ uptake, ↑ TSI–Thyroid Stimulating Ig level. See Exophthalmic goiter, Primary hyperthyroidism.

Graves' disease

The most common form of hyperthyroidism, characterized by bulging eyes, rapid heart rate, and other symptoms.
Graves' disease hyperthyroidism with goitre, characterized by diffuse thyroid hyperplasia

Patient discussion about Graves' disease

Q. Is there a recommended natural cure for graves disease? I've been suffering from graves for a year now and really feel tired of it. I'm thinking of trying some natural medications cause the regular ones are dissapointing so far. Any experience with that??

A. I am not familiar with any natural supplements you can take for graves disease, furthermore, it is an illness where you should be on close monitoring of an endocrinologist, and have them tell you which medications you are allowed to take and what could make the situation worse. If regular treatment doesn't seem to help you much you should go for another check up to see how your thyroid is doing.

Q. Is there a relation between certain types of allergies and graves? I suffer from graves and have been suffering from allergies since I was real young. Are these two related somehow?? anyone else suffers from both?

A. Not that I know about. However, allergy is quite common, and Graves' disease is also not a rare disease, so it's not impossible for the two to appear in the same person.

Take care,

More discussions about Graves' disease
References in periodicals archive ?
Table-3: Association of CD28 at C/T-I3 + 17 and that of CD40 at C/T-1 with Graves' disease.
Genotype and phenotype predictors of relapse of Graves' disease after antithyroid drug withdrawal.
The story of Graves' disease and its immunopathogenesis, assessment, and diagnostic testing technology continues to evolve.
Bone mineral density in patients of Graves' disease pre- & post-treatment in a predominantly vitamin D deficient population.
Neonatal Graves' disease: The prevalence of Graves' disease in pregnancy is about 0.
Comparison of efficacy and adverse effects between methimazole 15 mg + inorganic iodine and methimazole 30 mg/day as initial therapy for Graves' disease patients with moderate to severe hyperthyroidism.
Hyperthyroid Graves' disease was found to be related to significant changes in handwriting [17].
Kim WB, Han SM, Kim TY, Nam-Goong IS, Gong G, Lee HK Ultra sonographic screening for detection of thyroid cancer in patients with Graves' disease.
It took me two bouts of Graves' disease 5 years apart to really understand what this autoimmune hyperthyroidism is all about.
Graves' disease (GD) is an organ-specific autoimmune disorder characterized by hyperthyroidism with diffuse goiter and a possible presence of extra-thyroid manifestations such as eye changes (thyroid ophthalmopathy), skin change (dermopathy) and fingertips change (acropachy) [1, 2].
Graves' eye disease, also known as Graves' ophthalmopathy, would be present in about half of people who have Graves' disease, an autoimmune disorder and the treatment for the bulging eyes involved orbital decompression surgery, whereas, double vision was treated with a different surgery, which straightens the eyes by adjusting the eye muscles.