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Grapefruit Juice Effect

   Also found in: Wikipedia 0.01 sec.
Grapefruit Juice Effect
The effect that grapefruit juice has on the body, in particular, by increasing the effects of some drugs, due to the bergamottin in grapefruit juice, which blocks cytochrome P-450 CYP3A4 and CYP1A2, which in turn increases the serum levels of those drugs metabolised by those cytochrome P-450 pathways serum levels of certain drugs


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Bailey and his colleagues first stumbled across the grapefruit juice effect in 1989, while studying how alcohol interacts with a drug called felodipine, used to treat high blood pressure.
 
 
 
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