granulosa cell tumor

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granulosa cell tumor

 [gran″u-lo´sah]
an ovarian tumor originating in the granulosa cells, the solid mass of cells surrounding the graafian follicle; it may be associated with excessive production of estrogen, inducing endometrial hyperplasia with menorrhagia.

gran·u·lo·sa cell tu·mor

a benign or malignant tumor of the ovary arising from the membrana granulosa of the vesicular ovarian (graafian) follicle and frequently secreting estrogen; it is soft, solid, white or yellow, and consists of small round cells sometimes enclosing Call-Exner bodies; larger lipid-containing cells may be present.
Synonym(s): folliculoma (1)

granulosa cell tumor

[gran′yoo͡lō′sə]
Etymology: L, granulum, little grain
a fleshy ovarian tumor with yellow streaks that originates in cells of the primordial membrana granulosa and may grow to a large size. Excessive production of estrogen, resulting in endometrial hyperplasia and menorrhagia, may be associated with the tumor. Also called granulosa cell carcinoma.

granulosa cell tumor

Gynecology A sex cord tumor of older ♀ that comprises 1-2% of ovarian neoplasms, which is 'driven' by unopposed estrogen stimulation; the endometrium of Pts with GCTs often has cystic hyperplasia and 5-25% of Pts also have a concomitant well-differentiated endometrial CA

gran·u·lo·sa cell tu·mor

(gran'yū-lō'să sel tū'mŏr)
A benign or malignant tumor of the ovary arising from the membrana granulosa of the ovarian (graafian) follicle and frequently secreting estrogen.
Synonym(s): folliculoma (1) .

granulosa cell tumor

an ovarian stromal tumor originating in the solid mass of cells (granulosa cells) that surrounds the ovum in a developing graafian follicle. It may be associated with excessive production of estrogen, inducing endometrial hyperplasia and signs of hyperestrogenism. Most commonly observed in cows and mares, less commonly in the bitch, queen and ewe.
Enlarge picture
Granulosa cell tumor in a mare's ovary atnecropsy. By permission from Knottenbelt DC, PascoeRR, Diseases and Disorders of the Horse, Saunders, 2003
References in periodicals archive ?
Adult Granulosa cell tumour is the commonest tumour seen in our study.
In the malignant sex cord stromal group all tumours were granulosa cell tumours (7 cases; 11.
Mutational analysis of FOXL2 codon 134 in granulosa cell tumour of ovary and other human cancers.
Most ovarian tumours do not produce any hormones, except for the granulosa cell tumour (GCT) and, to a lesser extent the cystadenoma (Hinrichs et al.
Granulosa cell tumour of the testis displaying immunoreactivity for inhibin.
Granulosa cell tumour were the commonest Sex cord stromal tumours in our study (11/13) while studies carried out by Yasmeen et al [24] and R Zha et al [25] mentioned a variable incidence of 28.
The differential diagnosis of solid ovarian tumours includes rhabdomyosarcoma, extragonadal teratoma, neurogenic tumour, granulosa cell tumour and dysgerminoma.
Even though juvenile granulosa cell tumour (JGCT) of the testis only accounts for 1% to 5% of all prepubertal testis tumours,[sup.
JUVENILE granulosa cell tumour, as the name implies, usually presents in children before puberty.
4% Sex Cord Stromal Tumours 23 Granulosa Cell Tumour 7 3.
Granulosa cell tumour of the ovary in adults is a rare tumour of low malignant potential affecting middle aged peri or post menopausal patients.