Granulibacter bethesdensis is an emerging pathogen in patients with CGD that causes fever and necrotizing lymphadenitis.
Granulibacter bethesdensis is a recently described gram-negative bacterium in the family Acetobacteraceae; it has been isolated from 6 patients with CGD from North and Central America and Spain (7-10).
Genome sequence analysis of the emerging human pathogenic acetic acid bacterium Granulibacter bethesdensis.
Granulibacter bethesdensis isolated in a child patient with chronic granulomatous disease.
CHICAGO -- Integrated Genomics announced the publication of the complete Granulibacter bethesdensis genome sequence, the first acetic acid bacteria to be identified as an agent of an emerging invasive human disease.
Granulibacter bethesdensis is the first organism to be linked to chronic granulomatous disease (CGD), an invasive human disease resulting from a genetic defect in phagocyte superoxide formation.
Three species have been reported as emerging pathogens in humans: Asaia bogorensis (in a case of peritonitis in a patient with a peritoneal dialysis catheter ); Granulibacter bethesdensis
(in 3 cases of lymphadenitis associated with chronic granulomatous disease ); and Acetobacter cibinongensis (a recent case of bacteremia in a patient receiving chronic hemodialysis for end-stage renal failure ).