granule cell

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granule cell

1. Any of the small neurons that pack the granular cell layer of the cerebellar cortex, immediately below the Purkinje cell layer. Granule cells receive inputs (mossy fibers) from the spinal cord and brainstem (except the inferior olive). Axons of granule cells run perpendicular to the Purkinje cell dendrites, on which they synapse.
2. Any of the neurons of the cerebral cortex that are not pyramidal cells. Cortical granule cells are categorized as spiny or nonspiny. Synonym: stellate cell
3. A small axon-less neuron found in the olfactory bulb.
See also: cell


1. a small particle or grain.
2. a small pill made of sucrose.

acidophil g's
granules staining with acid dyes.
aleuronoid g's
colorless myeloid colloidal bodies found in the base of pigment cells.
alpha g's
1. oval granules found in blood platelets; they are lysosomes containing acid phosphatase.
2. large granules in the alpha cells of the islets of Langerhans; they secrete glucagon.
3. acidophilic granules in the alpha cells of the adenohypophysis.
amphophil g's
granules that stain with both acid and basic dyes.
azur g's, azurophil g's
granules that stain easily with azure dyes; they are coarse, reddish granules and are seen in many lymphocytes.
basophil g's
granules staining with basic dyes.
beta g's
1. granules in the beta cells of the islets of Langerhans that secrete insulin.
2. basophilic granules in the beta cells of the adenohypophysis.
granule cell
the largest group of cells produced by the external germinal layer on the external surface of the embryonal cerebellum; they form the thick granular layer of the cerebellum; called also granule neurons.
chromatic g's, chromophilic g's
see nissl bodies.
cone g's
the nuclei of the visual cells in the outer nuclear layer of the retina which are connected with the cones.
eosinophil g's
those staining with eosin. See also alpha granules (above).
epsilon granule
see neutrophil granules (below).
Grawitz's g's
minute granules seen in the erythrocytes in the basophilia of lead poisoning.
iodophil g's
granules staining brown with iodine, seen in polymorphonuclear leukocytes in various acute infectious diseases.
keratohyalin granule
keratin precursor; in the stratum granulosum of the epithelium.
metachromatic g's
granules present in mast cells and many bacterial cells, having an avidity for basic dyes and causing irregular staining of the cell.
mitochondrial g's
organelles in osteoblasts through which temporary calcium ion sequestration can be effected.
granule neurons
see granule cell (above).
neutrophil g's
neutrophilic granules from the protoplasm of polymorphonuclear leukocytes; called also epsilon granules.
Nissl's g's
see nissl bodies.
oxyphil g's
acidophil granules.
pigment g's
small masses of coloring matter in pigment cells.
primary g's
the peroxidase-positive granules of neutrophils, most prominent in the progranulocyte and early myelocyte stages.
rod g's
the nuclei of the visual cells in the outer nuclear layer of the retina which are connected with the rods.
secondary g's
the peroxidase-negative ('specific') granules seen in mature neutrophils.
seminal g's
the small granular bodies in the semen.
sulfur g's
see sulfur granule.
toxic g's
dark-staining granules in neutrophils that contain peroxidase and acid hydrolases. They occur in inflammatory reactions.
References in periodicals archive ?
Granular cell tumor of the esophagus: endoscopic ultrasonographic demonstration and endoscopic removal.
Granular cell tumors were first described by Abrikossoff in 1926.
Features Entities Masses and/or distortion Fat necrosis Radial scar/complex sclerosing lesion Granular cell tumor Spindle cell lesions Inflammatory conditions Chronic mastitis Idiopathic granulomatous mastitis Diabetic mastopathy Rare conditions Breast infarction Sarcoidosis Cooper's ligament
Meyer MA, Becker JM, Quinones W Endobronchial granular cell tumor: a case report.
The differential diagnosis of an oral mass in the newborn includes melanotic neuroectodermal tumour of infancy, malignant granular cell myoblastoma, alveolar rhabdomyosarcoma and chondrogenic and osteogenic sarcomas (5).
Malignant granular cell tumor of soft tissue: diagnostic criteria and clinicopathologic correlation.
Granular cell tumor (GCT) is a usually benign neoplasm of controversial Schwann cell origin.
Granular cell tumor, first described in 1856, has a long history of names (eg, myoblastic myoma) implying putative pathogenesis.
Epulis can be distinguished from more common granular cell tumors by its lack of pseudoepitheliomatous hyperplasia, the absence of S-100 protein expression, and a positive reaction to carcinoembryonic antigen and HLA-DR antigen.
Granular cell tumor is the most common benign, nonepithelial tumor occurring in the extrahepatic biliary ducts.
Other histologic subtypes also occur, often in the same tumor, including basal cell, granular cell, desmoplastic, and acanthomatous types.