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gram-negative
(redirected from Gram-negative bacterial infections)

   Also found in: Encyclopedia, Wikipedia 0.05 sec.
gram-negative /gram-neg·a·tive/ (-neg´ah-tiv) losing the stain or decolorized by alcohol in Gram's method of staining, characteristic of bacteria having a cell wall surface more complex in chemical composition than the gram-positive bacteria.
gram-negative or Gram-negative
adj.
Of, relating to, or being a bacterium that does not retain the violet stain used in Gram's method.

Gram-negative
Refers to the property of many bacteria that causes them to not take up color with Gram's stain, a method which is used to identify bacteria. Gram-positive bacteria which take up the stain turn purple, while Gram-negative bacteria which do not take up the stain turn red.

gram-negative
Etymology: Hans C.J. Gram, Danish physician, 1853-1938; L, negare, to say no
having the pink color of the counterstain used in Gram's method of staining microorganisms. This property is a primary method of characterizing organisms in microbiology. Some of the most common gram-negative pathogenic bacteria are Bacteroides fragilis, Brucella abortus, Escherichia coli, Haemophilus influenzae, Klebsiella pneumoniae, Neisseria gonorrhoeae, Proteus vulgaris, Pseudomonas aeruginosa, Salmonella typhi, Shigella dysenteriae, and Yersinia pestis.

gram-negative,
n having the pink color of the counterstain used in Gram's method of staining microorganisms. Staining property is a common method of classifying bacteria. See also Gram's stain.

gram-negative
said of bacteria that are decolorized by alcohol in Gram's method of staining (see gram's stain), and are thus stained only with the counter stain (usually red). Gram-negative bacteria have a much thinner layer of peptidoglycan in the cell wall than Gram-positive bacteria.


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The drug is currently also being studied in a second complicated skin infection trial (STRAUSS II) targeting both Gram-positive and Gram-negative bacterial infections, including patients with diabetic foot infections; and in phase III clinical trials in nosocomial pneumonia (CHOPIN studies) and in patients hospitalized with community-acquired pneumonia.
There is an urgent need for the development of new antibiotics to treat these and other gram-negative bacterial infections," said Steven Porter, Chairman and CEO of Ceragenix Pharmaceuticals.
nbsp;in liver transplant recipients has been associated with graft failure and a high mortality rate (4,5), and in gram-negative bacterial infections, the physiologic effects of endotoxin may persist after adequate antimicrobial drug treatment.
 
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