References in periodicals archive ?
Diagnostic work-up can be quite challenging given the high rate of concomitant pathologies present in these patients, including graft-vs-host disease and a wide array of opportunistic infections.
In addition, there are chapters devoted to transplantation topics, including solid-organ transplantation and hematopoietic stem cell transplantation, mononuclear cell transfusion, transfusion-associated graft-vs-host disease, and stem cell growth factors.
NASDAQ: OSIR), announced today it has received consent from New Zealand to market its first-in-class stem cell therapy Prochymal[R] (remestemcel-L), for the treatment of acute graft-vs-host disease (GvHD) in children.
The retrospective analysis involved 220 bone-marrow transplant patients who received methotrexate, an antifolate drug used as standard therapy for preventing graft-vs-host disease, a common complication of marrow transplantation.
In addition to preventing graft-vs-host disease in marrow-transplant patients, methotrexate is used to treat certain cancers and, in lower doses, immune diseases such as rheumatoid arthritis.
Graft-vs-host disease -- a complication associated with blood and bone marrow transplants
Although anti-tumor responses were seen in 33% of evaluable patients with blood cancers that had not responded to other treatments, most of these patients developed acute Graft-vs-Host Disease (GvsHD).
The INTERCEPT Blood System has received CE mark approvals for both the platelet and plasma systems, and may replace gamma irradiation for protection against transfusion-associated graft-vs-host disease.
DOR's lead product, orBec(R) (oral beclomethasone dipropionate), has recently completed enrollment in a multicenter, pivotal phase III clinical trial for the treatment of acute intestinal graft-vs-host disease, a form of serious and life-threatening gastrointestinal inflammation.
The Company's development pipeline includes: a drug candidate that controls cell proliferation and nutrient uptake by tumors to treat cancer; a bone-targeted drug candidate to treat the complications of cancer that has spread to bone; a regulated protein therapy product candidate to treat anemia in which the production of erythropoietin is controlled in vivo using an orally administered drug; a T cell immunotherapy product candidate in which a non-immunosuppressive drug may be used to treat graft-vs-host disease following donor bone marrow transplantation - a therapy for cancer and other immune and blood diseases; and dual-action drug candidates that block bone resorption and stimulate bone formation to treat osteoporosis.
Nasdaq: ARIA) today announced development of new clinical-scale methods for producing large numbers of therapeutic engineered donor T cells - an important milestone in the phase 2 development of the Company's product candidate to treat graft-vs-host disease.
Total expenses for the first quarter of 2002 were slightly lower than those for the fourth quarter of 2001, reflecting our vigorous efforts to prudently manage expenditures and yet to advance three of our hematology and oncology product candidates towards IND filings and our product candidate for graft-vs-host disease in phase 2 development," said Harvey J.