Pathogenic significance of alpha-N-acetylgalactosamine activity found in the envelope glycoprotein gp160
of human immunodeficiency virus type 1.
Drugs profiles discussed in this report includes AGS-67E, alemtuzumab, Antibody to Inhibit HLA-A2 for Neurology, Infectious Diseases and T-Cell Leukemia, BMS-906024, Cell Therapy to Target CD38 for cancer, IDD-003, INA-01, lenalidomide, MMIG-202, mogamulizumab, Monoclonal Antibodies to Antagonize TCR for Leukemia and Autoimmune Disease, Monoclonal Antibody to Target CCR9 for T Lymphoblastic Leukemia, NK-314, Oncolytic Virus to Target Glycoprotein gp160
for T-cell Leukemia, PCI-34051, PF-03084014, SL-101, Synthetic Peptide for Oncology and Male health, THV-02, TP-0903.
040 4+ ID Western blot results Remarks n=171 P55 P66 gP120 gP160
gP36 HIV-1 1 1+ 3+ 1+ 1+ Positive 2 3 1+ 3+ 1+ 1+ Positive 4 5 6 3+ 1+ 1+ Positive 7 1+ 4+ 1+ Positive 8 9 10 11 12 1+ 3+ 1+ 1+ Positive 13 1+=Weak positive; 2+=Moderate positive; 3+ and 4+=Strong positive; 8 out of 13 patients were first ELISA positive and second one negative; 5 patients were both ELISA positive and confirmed in western blot for HIV-1.
In particular, the HIV envelope spike, called gp160
, is the site of a host of mutations that obstruct the few elements that all of the virus strains share.
Vaccination of vaccinia-naive adults with human immunodeficiency virus type 1 gp160
recombinant vaccinia virus in a blinded, controlled, randomized clinical trial.
generation Oral fluids Plasma/Blood Viral Lysate and Bio-Rad Yes spot E-coli Laboratories recombinant antigen Third Serum/Plasma Recombinant HIV-1 Abbott Yes generation env and gag Laboratories HIV-2 env proteins Serum/Plasma Purified gp160
, Bio-Rad Yes p24, and Laboratories peptides representing regions of gp41 from HIV-1 group 0 and gp36 from HIV-2 Fourth Serum/Plasma HIV-1 gp160
, p24 bioMerieux No generation antigen, and Inc.
During the life cycle of HIV, the gp160
precursor protein is cleaved to form:
An EIA for HIV was positive, and a Western blot was positive with bands present for p24, gp40, p55, and gp160
Protease inhibitors prevent the cleavage of gp160
into gp41 and gp120.
Repeat HIV serologic testing showed a positive HIV enzyme immunoassay and a positive Western blot with bands at gp120, gp160
, and p24.
Initially, the group created intrabodies that fuse to gp160
, a precursor of the protein that makes up HIV's outer envelope.
It sells proteins including HIV antigens (P24, GP160
, GP120, P66 and P55) to the research market.