gp120


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Related to gp120: CD4, CCR5

gp120

(jē′pē′wən-twĕn′tē)
n.
A glycoprotein that protrudes from the surface of the HIV virus and binds to the glycoprotein CD4 in human cells.

gp120

HIV A 120 kD glycoprotein on the surface of HIV-1, which binds to cells–T cells, macrophages at the CD4 receptor. See AIDS, AIDS vaccine, HIV.

gp120

A glycoprotein found on the outer surface of the HIV virus. It facilitates binding of the virus to CD4+ lymphocytes. Its molecular weight is 120 kD.
References in periodicals archive ?
To get around that, according to the university, the researchers found a piece of the gp120 protein that was common to many different HIV strains and used that to create their vaccine component, along with a sugar molecule that is likewise common to the strains.
A sugar shield covers the gp120 envelope, bolstering HIV's defenses.
The enhancement of ROS production is mediated by the envelope protein Gp120 [79-85], Tat [83, 84, 86-88], Nef [89-91], Vpr [71, 92, 93], and reverse transcriptase (RT) [94].
These study results strongly suggest that glycoprotein gp120 or gp120/gp4i induces adsorptive endocytosis and the uptake of HIV-1 by brain endothelial cells.
Limiting analysis to the V3 loop of gp120 is less difficult but may yield less accurate results since regions outside V3 are also involved in viral tropism.
T cells, macrophages, dendritic cells) with HIV, uncontrolled viral replication that impairs antigen presentation, increased mutations in env protein gp120 that leads to virus tropism and survival, increased activation of T helper cells by alloantigens, increased apoptosis by activated [CD4.
15 Con un novedoso mecanismo de accion, previene una interaccion inicial entre el virus y la celula del hospedero, tras unirse directamente a la proteina viral, gp120, previo a la union con el receptor CD4 (pre-CD4), bloquea la conformacion final consolidada entre la gp120 y el receptor celular CD4.
El empalme de los viriones con las celulas T y celulas T CD4 especializadas es posible por la glicoproteina gp120 ubicada en la envoltura del virus y las moleculas CD4 en la superficie de las celulas T.
La entrada del VIH a la celula no solo esta mediada por la union de la glicoproteina viral gp120 con el receptor celular CD4, es necesario que se genere una segunda interaccion con un correceptor celular bien sea CCR5 o CXCR4.
Moreover, CD4 is the receptor of human immunodeficiency virus (HIV) gp120 envelope glycoprotein (Wyatt et al.
This process requires the trimeric viral envelope glycoprotein gp160, which is lysed by a single proteolytic reaction, and then the stable associated Gp120, Gp41 is formed.