Gorlin-Goltz syndrome is a rare genetic disease with autosomal dominant inheritance that leads to multi-organ disorder.
In a case of early-onset Gorlin-Goltz syndrome reported recently in the literature, a total of three tumors including BCC, fetal rhabdomyoma, and an adnexial tumor-like skin tumor, were found in a 22-month-old female patient (5).
Multiple lesions are associated with Gorlin-Goltz syndrome
or nevoid basal cell carcinoma syndrome.
Successful Treatment of Multiple Basaliomas with Bleomycinbased Electrochemotherapy: A Case Series of Three Patients with Gorlin-Goltz Syndrome
Furthermore, the KOTs that affect patients with Gorlin-Goltz syndrome
commonly behave more aggressively, (7) most likely due to the higher rate of epithelial proliferation that occurs in these patients.
Marathon of eponyms: 7 Gorlin-Goltz syndrome (Naevoid basal-cell carcinoma syndrome).
Clinical and dermatoscopic findings in BazexDupre-Christol and Gorlin-Goltz syndromes.
Nevoid basal cell carcinoma syndrome (NBCCS), also known as basal cell nevus syndrome, multiple basal cell carcinoma syndrome, Gorlin syndrome, and Gorlin-Goltz syndrome
, is an inherited medical condition involving defects within multiple body systems such as the skin, nervous system, eyes, endocrine system, and bones.
(also known as nevoid basal cell carcinoma syndrome) was first reported in 1894, but described by Gorlin and Goltz in 1960 as a distinct entity consisting of ectodermal and mesodermal abnormalities.
The gene is part of the same pathway implicated in nevoid basal cell carcinoma syndrome (NBCCS) or Gorlin-Goltz syndrome
, though its expression is less severe.
NBCCS is also known as Gorlin-Goltz syndrome
, Gorlin's syndrome, and basal cell nevus syndrome.
Incidence of OKCs in patients with Gorlin-Goltz syndrome
according to age, gender and location.