OTCQB:HPPI), a clinical stage biopharmaceutical company that discovers, develops and plans to commercialize innovative therapeutics for patients with cancer, announced today that initial patients have received base-line screening and the first of those patients has begun dosing in HPPI's Phase II(b) clinical trial examining SUBA(TM) Itraconazole Capsules as a potential therapy for basal cell carcinoma (BCC) in patients with basal cell carcinoma nevus syndrome (BCCNS), also known as Gorlin's Syndrome
I have facial disfigurement because of Gorlin's syndrome
A 10-year-old girl with Gorlin's syndrome presented for evaluation of bilateral tonsillar lesions.
Gorlin's syndrome (basal cell nevus syndrome) is an autosomal-dominant disorder with complete penetrance and variable expression.
The hedgehog pathway caught the attention of cancer researchers when studies revealed that people with Gorlin's syndrome
, a hereditary condition that leaves a person highly susceptible to medulloblastoma, often lack a protein that acts as a brake on the pathway, says Berman.
The IND covers HPPI's clinical development plan for a patented formulation of itraconazole (known as SUBA-Itraconazole) with improved bioavailability to study the treatment of basal cell carcinoma (BCC) in patients with basal cell carcinoma nevus syndrome (BCCNS), also known as Gorlin's syndrome
, an orphan disease with no approved pharmaceutical therapy.
NBCCS is also known as Gorlin-Goltz syndrome, Gorlin's syndrome
, and basal cell nevus syndrome.
with associated odontogenic cysts.