HPPI will study the efficacy and safety of twice-daily dosing of SUBA-Itraconazole Oral Capsules as a potential therapy for basal cell carcinoma in patients with basal cell carcinoma nevus syndrome (BCCNS), also called Gorlin's Syndrome
The nevoid BCC syndrome or Gorlin's syndrome
is a condition with significant oral, head and neck involvement that occurs at a younger age (under 30 years) and should be recognized by dentists.
It has been explored that medullated nerve fibres are a sign of Gorlin's syndrome - a feature of which is intracranial calcification.
Since our patient's MRI also revealed the same, whether it is an early step in the pathogenesis of Gorlin's syndrome needs further evaluation.
I have facial disfigurement because of Gorlin's syndrome
A 10-year-old girl with Gorlin's syndrome presented for evaluation of bilateral tonsillar lesions.
Gorlin's syndrome (basal cell nevus syndrome) is an autosomal-dominant disorder with complete penetrance and variable expression.
The hedgehog pathway caught the attention of cancer researchers when studies revealed that people with Gorlin's syndrome
, a hereditary condition that leaves a person highly susceptible to medulloblastoma, often lack a protein that acts as a brake on the pathway, says Berman.
NBCCS is also known as Gorlin-Goltz syndrome, Gorlin's syndrome
, and basal cell nevus syndrome.
with associated odontogenic cysts.