gonadotrophin

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gonadotropin

 [go´nah-do-tro″pin]
any hormone having a stimulating effect on the gonads. Two such hormones are secreted by the anterior pituitary gland: follicle-stimulating hormone and luteinizing hormone, both of which are active, but with differing effects, in the two sexes. Called also gonadotropic hormone.
chorionic gonadotropin (human chorionic gonadotropin (HCG) (hCG))
1. a glycopeptide hormone that is produced by cells of the fetal placenta and maintains the function of the corpus luteum during the first few weeks of pregnancy. It is thought to promote steroidogenesis in the fetoplacental unit and to stimulate fetal testicular secretion of testosterone. It can be detected by immunoassay in the maternal urine within days after fertilization; this provides the basis for the most commonly used pregnancy test.
2. the same principle obtained from the urine of pregnant women, used in treatment of certain cases of cryptorchidism and male hypogonadism, to induce ovulation and pregnancy in certain infertile, anovulatory women, and to increase the numbers of oocytes for patients attempting conception using assisted reproductive technologies such as gamete intrafallopian transfer or in vitro fertilization; administered intramuscularly. See also choriogonadotropin alfa.

go·nad·o·tro·pin

(gō'nad-ō-trō'pin, gon'ă-dō-),
1. A hormone capable of promoting gonadal growth and function; such effects, as exerted by a single hormone, are usually limited to discrete functions or histologic components of a gonad, such as stimulation of follicular growth or of androgen formation; most gonadotropins exert their effects in both genders, although the effect of a given gonadotropin will differ in males and females.
2. Any hormone that stimulates gonadal function.
3. Any substance that has the combined effects of follicle-stimulating hormone and luteinizing hormone.

go·nad·o·tro·pin

(gō-nad'ō-trō'pin)
1. A hormone capable of promoting gonadal growth and function; such effects, as exerted by a single hormone, usually are limited to discrete functions or histologic components of a gonad, such as stimulation of follicular growth or of androgen formation; most gonadotropins exert their effects in both sexes, although the effect of a given gonadotropin will differ in males and females.
Synonym(s): gonadotrophin.
2. Any hormone that stimulates gonadal function.
3. Any substance that has the combined effects of follicle-stimulating hormone and luteinizing hormone.

gonadotrophin

or

gonadotrophic hormones

hormones secreted by the anterior lobe of the PITUITARY GLAND and in some mammals, once pregnancy is under way, by the PLACENTA. FSH and LH are produced by all TETRAPODS though FSH appears to be absent in fish. LTH (Luteotrophin) is present in rats and maintains the CORPUS LUTEUM though it is absent in other mammals. Prolactin is present in some vertebrates and controls milk production (LTH is a form of prolactin). Pituitary output is controlled by the hypothalamus. Gonadotrophins influence other glands connected with reproduction, controlling the activity of the gonads, the onset of sexual maturity, OESTROUS CYCLES, breeding rhythms and LACTATION. See also HCG.

Gonadotrophin

Hormones that stimulate the ovary and testicles.
Mentioned in: Klinefelter Syndrome

gonadotrophin

; gonadotropin hormone secreted by both sexes; promotes gonadal growth and function
  • anterior pituitary gonadotrophin pituitary gonadotrophic hormone of hypophyseal origin

  • chorionic gonadotrophin; CG; human chorionic gonadotrophin; hCG placental hormone, excreted in urine of pregnant women

gonadotrophin (gōnad´ōtrōf´in),

gonadotrophin

References in periodicals archive ?
During growth and development, ovarian follicles undertake a series of complex biochemical and physiological changes that include gonadotropin receptor expression, steroid biosynthesis, cell proliferation and differentiation.
highlight the important potential for the glycoprotein hormone degradation products to cross-react in gonadotropin and thyrotropin assays.
During aging, the FSH levels are relatively high, but the biological activity of the gonadotropin is low, says Hsueh, adding that circulating antihormones could explain the discrepancy.
Active immunization of gilts against gonadotropin-releasing hormone: effects on secretion of gonadotropins, reproductive function, and responses to agonists of gonadotropin-releasing hormone.
Additional studies assessed the benefits of once-daily combined gonadotropin dosing compared with twice-daily dosing, and the safety and efficacy of MENOPUR(R) (menotropins for injection, USP) in polycystic ovarian syndrome (PCOS) patients.
Type of gonadotropin preparation did not predict poor ovarian response.
Improved pregnancy outcome with the addition of leuprolide acetate to gonadotropins for in vitro fertilization.
Human menopausal gonadotropins have been the cornerstone of fertility treatment for nearly 50 years," said Wayne Anderson, President, Ferring Pharmaceuticals.
Letrozole, an aromatase inhibitor, was originally used for ovarian stimulation in infertility patients who responded poorly to clomiphene citrate or gonadotropin stimulation.
Human chorionic gonadotropin (hCG) is the intact heterodimer, consisting of an [alpha]- and a [beta]-subunit.
We believe that the age-related increases in pituitary gonadotropins, (luteinizing hormone and follicle stimulating hormone) seen in older men and during menopause in women, cause the brain changes that characterize Alzheimer's disease," said Dr.
Michael Kettel of the San Diego Fertility Center, noted that the study's design gives it credence and may convince otherwise impatient fertility patients to give the strategy a try Considerable cost savings can be achieved, while minimizing risks of gonadotropin therapy (See accompanying story and chart.