Effects of toxic levels of lead on gene regulation in the male axis: increase in messenger ribonucleic acids and intracellular stores of gonadotrophs
within the central nervous system.
24) However, prolonged stimulation of GnRH receptors leads to reduced numbers of receptors, blocking the action of GnRH pulses on the gonadotrophs
, preventing the secretion of LH pulses and decreasing FSH secretion, leading to down-regulating the HPG axis.
Effects of an indigenous contraceptive herbal formulation on gonadotrophs
of the pituitary gland of the rat.
Special cells inside the pituitary known as gonadotrophs produce hormones (specifically gonadotropin-releasing hormone and luteinizing hormone, or LH) that control ovulation and fertility.
The researchers previously discovered that gonadotrophs harbor insulin receptors, but no one really knew what the effect of insulin on those receptors was.
The investigators focused on a class of pituitary cells called gonadotrophs
, which secrete luteinizing hormone (LH), critical for ovulation and fertility.
Asubstance with hCG-like properties was 1st identified in the pituitary gland in 1976 and was subsequently localized to gonadotrophs
The most vulnerable cells include somatotrophs and gonadotrophs
However, it is tempting to speculate that the prolonged status of decreased E2 synthesis due to a lack of the substrate (T) evoked the desensitization of either hypothalamic gonadotropin-releasing hormone neurons or FSH-synthesizing gonadotrophs
in the pituitary.
Possible interactions between gonadotrophs
and somatotrophs in the pituitary of tilapia: apparent roles for insulin-like growth factor I and estradiol.
Replenishment of LH stores of gonadotrophs
in relation to gene expression, synthesis and secretion of LH after the preovulatory phase of the sheep oestrous cycle.
Any true hCG[beta]cf, derived from extremely low-level expression of the hCG[beta] gene cluster by pituitary gonadotrophs
, is likely to be extremely low and much smaller than immunoreactivity from cross-reacting [beta]-LH-core metabolite.