Goldie-Coldman Hypothesis

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A posit that the emergence of chemotherapy-resistant subclones of malignant cells arise at a rate related to the genetic instability. Resistance is a process of selection. Rate of development of drug resistance is independent of number of cells, but the absolute number of resistant cells is still greater

Goldie-Coldman hypothesis

a theory relating drug resistance to spontaneous cell mutations; it is used to justify the use of multiple agents in chemotherapy of tumors.

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