carcinoids and related tumors of the vermiform appendix.
The most common types were pseudostratified cylindrical ciliated epithelium with goblet cells
(figures 2 and 3), stratified cuboidal epithelium (figures 4 and 5), and stratified squamous nonkeratinized epithelium (figures 6 and 7).
First, immunohistochemical studies have found that non-goblet cell
columnar epithelium is essentially intesfinalized, even though goblet cells
are not identified.
According to the WHO classification, endocrine tumors of the appendix are defined as (1) a well-differentiated endocrine tumor with benign behavior (confined to the appendiceal wall, with a diameter [less than or equal to] 2 cm and without angioinvasion) or uncertain behavior (confined to the subserosa or with a maximal diameter >2 cm or angioinvasion); (2) a well-differentiated endocrine carcinoma (invading the mesoappendix or beyond and/ or with metastases); or (3) goblet cell
A dual differentiation of tumor cell type is seen within the nests: neuroendocrine cells with eosinophilic, granular cytoplasm, and mucinous goblet cells
of gastrointestinal type.
If mBAC can be considered the prototype of a tumor with differentiated bronchiolar goblet cell
features, the assignment of the adenocarcinomas exhibiting intestinal markers appears less obvious, as previously discussed.
The presence of intestinal-type goblet cells
(ITGCs) in sections of endoscopic esophageal biopsies is considered essential for the diagnosis of Barrett metaplasia (BM).
The goblet cells
are variably present either in the base or on the surface.
The tumor was composed of adenomatous groups of goblet cells
containing predominantly vacuolated cytoplasm with basal round to crescentic nuclei containing a single small nucleolus.
Periodic acid-Schiff stain stains neutral goblet cells
magenta; Alcian Blue stains acidic mucins blue.
The surface layer is composed of ciliated epithelial cells and mucus-secreting goblet cells
Cells from the tops of colon crypts showed profiles compatible with mature enterocytes, whereas cell groups from the bottoms of crypts showed profiles compatible with immature cells, goblet cells
, and stem cells/progenitor cells.