gonadotropin-releasing hormone analogue

(redirected from GnRH analogues)
Also found in: Wikipedia.

gonadotropin-releasing hormone analogue

A polypeptide analogue of gonadotropin-releasing hormone–GnRH; some are more potent than GnRH in stimulating gonadotropin release Examples Leuprolide, histrelin, administered in a pulsatile fashion to restore lost GnRH, normalize pituitary-gonadal function, as in congenital GnRH deficiencies–eg, hypogonadotropic hypogonadism with Kallmann syndrome or without anosmia, or in acquired GnRH deficiency secondary to RT of the CNS, pituitary tumors, or panhypopituitarism. See Gonadotropin-releasing hormone.
References in periodicals archive ?
Among patients treated for IVF with gonadotrophins and GnRH analogues, is the probability of live birth dependent on the type of analogue used?
3] The hypothesis was that GnRH antagonists, which maximally inhibit follicle-stimulating hormone (FSH) levels, would be associated with reduced adiposity, the development of metabolic syndrome and CV disease compared to GnRH analogues and orchiectomy.
All these treatments are contraceptive and include ongoing use of high-dose oestrogens and/or progestogens or drugs called GnRH analogues, to suppress ovarianstimulating hormones.
The introduction of newer GnRH analogues, the GnRH antagonists, created the potential for milder stimulation protocols that are better tolerated and less costly, have a quicker onset of action, result in a lower incidence of luteinising hormone (LH) surge, and are associated with a lower multiple pregnancy rate.
The present study demonstrated that spermiation success in Caspian brown trout can be obtained by the administration of three different GnRH analogues, mammalian (D-Ala6,Pro9-Net mGnRHa), (D-Trp6-mGnRH) and salmon (D-Arg6,Pro9-Net sGnRHa, trade mark Ovaprim) combined with two different dopamine antagonists.
The use of GnRH analogues has been explored in relation to breast cancer treatment as a form of ovarian protection on the basis that the use of these drugs will lead to a low oestrogen state and ovarian suppression, thereby 'resting' the ovaries during cytotoxic treatment.
Precocious puberty can effectively be treated with GnRH analogues.
Although GnRH analogues can be given for 6 months, longer treatment is associated with high cost and significant side effects.
Several different hormonal approaches are available for prostate cancer including bilateral orchiectomy (surgical removal of the testicles), GnRH analogues and anti-androgens.
In this research, Frost & Sullivan's expert analysts thoroughly examine the following markets: GnRH analogues, progestins and danazols.
GnRH analogues have been used prior to myomectomy and there is clear evidence that their use reduces uterine volume and fibroid size and reduces blood loss and operating time during myomectomy (16, 17).
35) Further complicating the current understanding of the pharmacology of GnRH analogues in avian species is the existence of 2 forms of GnRH in the chicken.