gonadotropin-releasing hormone analogue

(redirected from GnRH analogues)

gonadotropin-releasing hormone analogue

A polypeptide analogue of gonadotropin-releasing hormone–GnRH; some are more potent than GnRH in stimulating gonadotropin release Examples Leuprolide, histrelin, administered in a pulsatile fashion to restore lost GnRH, normalize pituitary-gonadal function, as in congenital GnRH deficiencies–eg, hypogonadotropic hypogonadism with Kallmann syndrome or without anosmia, or in acquired GnRH deficiency secondary to RT of the CNS, pituitary tumors, or panhypopituitarism. See Gonadotropin-releasing hormone.
References in periodicals archive ?
Furthermore, our study did not compare UAE to other treatment modalities such as hysterectomy and GnRH analogues.
When an individual is committed to preventing the development of secondary sex characteristics, GnRH analogues ('blockers') can be administered to halt development of puberty.
6,7) GnRH analogues lead to the desensitisation of pituitary GnRH receptors and block endogenous LH increase.
In the long protocol, downregulation was achieved using GnRH analogues initiated at the start of the proceeding luteal phase, with dosing halved beginning on the day of hyperstimulation and continued until the day of hCG treatment.
The contract is the supply of medicines containing GnRH analogues and anti-estrogens for 2 years according to the current needs of the client.
One of the methods for protecting female reproductive function and for preventing ovarian damage is the administration of GnRH analogues (GrRH-a) during CHT.
These specialists can work with patients and families, and determine when and if youth are eligible for puberty blocking therapy with GnRH analogues and / or hormone therapy.
Synthetic hormone compounds, such as mammalian GnRH analogues, have been successfully tested to induce fish reproduction (DAS, 2000; 2004; ULIKOWSKI, 2004; KROL et al.
GNRH analogues: GNRH analogues have been used in conjunction with gandotrophins to achieve pituitary down regulation and to facilitate cycle control.
3] The hypothesis was that GnRH antagonists, which maximally inhibit follicle-stimulating hormone (FSH) levels, would be associated with reduced adiposity, the development of metabolic syndrome and CV disease compared to GnRH analogues and orchiectomy.
All these treatments are contraceptive and include ongoing use of high-dose oestrogens and/or progestogens or drugs called GnRH analogues, to suppress ovarianstimulating hormones.
Although GnRh analogues are used effectively for treatment of pelvic endometriosis but there was no change in size of lesion11.