overcome tetracycline resistance due to both ribosomal protection and efflux determinants.
All isolates tested were susceptible to all non-[beta]-lactam antibacterial agents, comprising glycopeptides, lipopeptides, fluoroquinolones, macrolides, lincosamides, oxazolidinones, rifampins, streptogramins, glycylcyclines
, folate pathway inhibitors, aminoglycosides, and fosfomycin.
Tigecycline, the first of a new class of broad-spectrum antibiotics, the glycylcyclines
, was recently licensed in South Africa for the parenteral treatment of adult patients with complicated intra-abdominal infections (cIAIs) and complicated skin and soft-tissue infections (cSSTIs).
Tigecycline, the first of a novel class of broad-spectrum antibiotics, the glycylcyclines
, was recently licensed in South Africa for the parenteral treatment of adult patients with complicated skin and soft-tissue infections (cSSTIs) and complicated intra-abdominal infections (cIAIs).
In this scenario, the development of a new class of antimicrobial agents, glycylcyclines
, represented by tigecycline, a 9-t-butylglyclamide derivative of minocycline is a significant advancement (2-5).
This insight was further expanded by the medicinal chemistry team as part of the strategy which led to the discovery of Tygacil(R) (tigecycline), the first in a new class of intravenous antibiotics, glycylcyclines
were developed to help overcome these resistance mechanisms.
2005 has seen the launch of the first in a new class of antibiotics, the glycylcyclines
The few therapeutic options for treating infections caused by organisms containing these [beta]-lactamases are aminoglycosides, glycylcyclines
, polymyxins, or combinations (1).
Tigecycline, the first agent of the new broad-spectrum class of glycylcyclines
, has been shown to have excellent activity against Gram-negative pathogens including ESBL-producing isolates, Acinetobacter spp.
TYGACIL, the first antibiotic approved in a new class called glycylcyclines
, was developed by Wyeth to overcome key mechanisms of resistance that have affected antibiotic use.
Tygacil is the first in a new class of antibiotics called glycylcyclines
to be submitted for regulatory approval.