Various studies have established an association between elevated titers of antibodies against sulfatide (the main acidic glycosphingolipid
component of the myelin sheath) and a number of systemic and neurologic disorders.
coli to glycosphingolipids
of the lipid-double-membrane of renal cells precedes renal parenchymal invasion (Rice et al.
In substrate reduction therapy (SRT), the synthesis of glycosphingolipids
is reduced by partial inhibition of glucosylceramide (G1cCer) synthase by deoxynojirimycin analogs (5), leading to reduction of the glycosphingolipid
pool and eventually to reduction of the substrate load for lysosomal degradation by sphingolipid hydrolases.
INCI: Water, perfluordecalin, propylene glycol, glycerin, simondsia chinensis, PEG-75 shea butter glycerides, glycosphingolipids
, xanthan gum, phenoxyethanol, benzoic acid, dehydroacetic acid
alpha-galactosidase A catalyzes the hydrolysis of globotriaosylceramide (GL-3) and other alpha-galactyl-terminated neutral glycosphingolipids
, such as galabiosylceramide and blood group B substances to ceramide dihexoside and galactose.
in Bomirski transplantable melanomas in hamsters.
Some Gram-negative bacteria are known to contain glycosphingolipids
instead of LPS in their OM (Kawahara et al.
M3] gangliosides (50), and other glycosphingolipids
INCI name: glycosphingolipids
A new study, which appeared in the journal, Antiviral Research 56 (2002) 233-251, titled, "A post-CD4-binding step involving interaction of the V3 region of viral gp120 with host cell surface glycosphingolipids
is common to entry and infection by diverse HIV-1 strains; by Nehete, Vela, Hossain, Sarkar, Yahi, Fantini and Sastry," indicated that testing conducted by M.
For example, the ubiquitous [alpha]2,6-sialyltransferase ST6Gal I recognizes the N-acetyllactosamine unit and catalyzes the formation of an [alpha]2,6 linkage to terminal N-acetyllactosamine structures found on N-glycans, O-glycans, and glycosphingolipids
, whereas the [beta]1,4-galactosyltransferase (Gal-T1) galactosylates any terminal Glc- NAc residue.
In the skin, ceramides may be found free or included in more complex lipids such as sphingomyelin or various glycosphingolipids
in the inter-cellular spaces.