glycosphingolipids


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glycosphingolipids

[glī′kōsfing′gōlip′ids]
compounds formed from carbohydrates and ceramide, a fatty substance, found in tissues of the central nervous system and also in erythrocytes. Deficiency of an enzyme needed to metabolize glycosphingolipids leads to a potentially fatal nervous system disorder.

glycosphingolipids

(glī″kō-sfĭng″ō-lĭp′ĭds)
A group of carbohydrate-containing fatty acid derivatives of ceramide. Three classes of these lipids are cerebrosides, gangliosides, and ceramide oligosaccharides. When the enzymes essential to the metabolism of these compounds are absent, the glycosphingolipids accumulate, particularly in the nervous system. Death is the usual outcome.
References in periodicals archive ?
Various studies have established an association between elevated titers of antibodies against sulfatide (the main acidic glycosphingolipid component of the myelin sheath) and a number of systemic and neurologic disorders.
coli to glycosphingolipids of the lipid-double-membrane of renal cells precedes renal parenchymal invasion (Rice et al.
In substrate reduction therapy (SRT), the synthesis of glycosphingolipids is reduced by partial inhibition of glucosylceramide (G1cCer) synthase by deoxynojirimycin analogs (5), leading to reduction of the glycosphingolipid pool and eventually to reduction of the substrate load for lysosomal degradation by sphingolipid hydrolases.
INCI: Water, perfluordecalin, propylene glycol, glycerin, simondsia chinensis, PEG-75 shea butter glycerides, glycosphingolipids, xanthan gum, phenoxyethanol, benzoic acid, dehydroacetic acid
alpha-galactosidase A catalyzes the hydrolysis of globotriaosylceramide (GL-3) and other alpha-galactyl-terminated neutral glycosphingolipids, such as galabiosylceramide and blood group B substances to ceramide dihexoside and galactose.
Glycosphingolipids in Bomirski transplantable melanomas in hamsters.
Some Gram-negative bacteria are known to contain glycosphingolipids instead of LPS in their OM (Kawahara et al.
M3] gangliosides (50), and other glycosphingolipids (51).
INCI name: glycosphingolipids (and) digalactosyldiglycerides
A new study, which appeared in the journal, Antiviral Research 56 (2002) 233-251, titled, "A post-CD4-binding step involving interaction of the V3 region of viral gp120 with host cell surface glycosphingolipids is common to entry and infection by diverse HIV-1 strains; by Nehete, Vela, Hossain, Sarkar, Yahi, Fantini and Sastry," indicated that testing conducted by M.
For example, the ubiquitous [alpha]2,6-sialyltransferase ST6Gal I recognizes the N-acetyllactosamine unit and catalyzes the formation of an [alpha]2,6 linkage to terminal N-acetyllactosamine structures found on N-glycans, O-glycans, and glycosphingolipids, whereas the [beta]1,4-galactosyltransferase (Gal-T1) galactosylates any terminal Glc- NAc residue.
In the skin, ceramides may be found free or included in more complex lipids such as sphingomyelin or various glycosphingolipids in the inter-cellular spaces.