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Elevated levels of methionine in the sera.
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a) [up arrow] [up arrow] Cystathionine [beta]-synthase deficiency N (homocystinuria) (a) Cbl metabolism Adenosyl-Cbl-specific deficiencies Cbl A, (a) Cbl B, (a) and Cbl D-Var2 [up arrow] (b) deficiencies Combined methyl-Cbl and adenosyl-Cbl cbl metabolism Cbl C, (c) Cbl D, (c) and Cbl F (b) [up arrow] deficiencies Methyl-Cbl-specific deficiencies Cbl D-Var1, Cbl E, and Cbl G N deficiencies (b) Met adenosyltransferase I/III deficiency (c) N Adenosylhomocysteine hydrolase deficiency (c) N Glycine N-methyltransferase deficiency (c) N Methylene tetrahydrofolate reductase N deficiency (b) Nutritional Cbl deficiency in mother or N to [up arrow] other Cbl metabolism defect (b) (e.