Kainic Acid-mediated Neural Cell Death in Brain: Interplay among Glycerophospholipid
, Sphingolipid-, and Cholesterol-derived Lipid Mediators
The derivations of those biomarkers can be regulated by administration of XKS, which suggested that the intervention effect of XKS against AS may involve in regulating the lipid perturbation including fatty acid [beta]-oxidation pathway, sphingolipid metabolism, glycerophospholipid
metabolism and bile acid biosynthesis.
TAHIRA FAROOQUI has published extensively on drug receptor interactions, biogenic amines in vertebrate and invertebrate nervous systems, glycerophospholipid
and sphingolipid metabolism, and molecular mechanisms in the brain, as well as on the neuromodulatory role of octopamine in the reinforcement pathway involved in olfactory learning and memory.
In total, 25 lipid-related resonances could be assigned, leading to the identification of 9 molecular species: free cholesterol, esterified cholesterol, 7-lathosterol, triglycerides, spingomyelin, choline, glycerophospholipid
, phosphatidylcholine, and fatty acids (esterified plus nonesterified; Table 1).
Platelet-activating factor (PAF), a potent glycerophospholipid
mediator, is involved in a number of dose-dependent physiological functions such as platelet and neutrophil aggregation, inducement of changes in vascular permeability, anaphylaxis and hypotension (Blank et al.
A total of 116 lipids were identified and quantified by UPLC-TOF ESI-positive mode that were distributed as follows: five classes of glycerophospholipids
[phosphocholine (PC) with 20 lipids, lysophosphatidylcholine (LPC) with 6 lipids, phosphatidylethanolamine (PE) with 9 lipids, phosphatidylserine (PS) with 7 lipids, and phosphatidylinositol (PI) with 3 lipids]; diacylglycerols (DG) with 20 lipids; triacylglycerols (TG) with 39 lipids; cholesterylesters (CE) with 4 lipids; and sphingolipids (SM) with 8 lipids.
Seasonal acquisition of chill tolerance and restructuring of membrane glycerophospholipids
in an overwintering insect: triggering by low temperature, desiccation and diapause progression.
SimLipid already supports precursor search and structural elucidation for Glycerophospholipids
, Glycerolipids, Prenol Lipids and Saccharolipids.
Of the 163 possible metabolites initially evaluated, 92 involved glycerophospholipids
2] enzymes are members ofa large family that hydrolyze the sn-2 ester of glycerophospholipids
to release free fatty acids and lysophospholipids.
Phospholipids with a glycerol backbone are known as glycerophospholipids
Fatty-acid composition of glycerophospholipids
in 7 tissues of cod (Gadus morhua), determined by combined high performance liquid chromatography and gas-chromatography.