coeliac disease

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Related to Gluten intolerance: celiac disease, lactose intolerance, Gluten free diet

coeliac disease

A malabsorptive syndrome caused by hypersensitivity of intestinal mucosa to alpha-gliadin, a gluten extract composed of glutamine and proline-rich proteins that is found in wheat, barley, rye, and oats.
 
Clinical findings
Diarrhoea, copious fatty stools, abdominal distension, weight loss, haemorrhage, osteopenia, muscle atrophy, peripheral neuropathy, CNS and spinal cord demyelination (sensory loss, ataxia), amenorrhoea, infertility, oedema, petechiae, dermatitis herpetiformis (especially if HLA B27), alopecia areata. Occult bleeding occurs in half of patients.
 
Lab
Transaminases (ALT, AST) are increased in ± 40% of patients with CD, which usually normalises with a gluten-free diet; iron deficiency, anaemia due to occult bleeding.

Diagnosis
Duodenal biopsy; anti-gliadin and anti-endomysial antibodies.
 
Management
Eliminate gliadin from diet.

Prognosis
Without treatment, 10–15% develop lymphoma (e.g., immunoblastic lymphoma; less commonly, T cell lymphoma), a risk that increases with disease duration. CD predisposes to gastrointestinal lymphoma and carcinoma of the oral cavity and oesophagus; the otherwise rare small intestinal adenocarcinoma is 80-fold more common in CD.

ce·li·ac dis·ease

(sē'lē-ak di-zēz')
A disease occurring in children and adults characterized by sensitivity to gluten, with chronic inflammation and atrophy of the mucosa of the upper small intestine; manifestations include diarrhea, malabsorption, steatorrhea, and nutritional and vitamin deficiencies.
Synonym(s): gluten enteropathy, coeliac disease.

coeliac disease

An intestinal disorder caused by intolerance to the gluten proteins the gliadins, hordeins and secalins in wheat, barley and rye. The intestinal mucosa becomes infiltrated with CD8 and CD4 lymphocytes (T cells) leading to crypt hyperplasia and atrophy of the absorbing VILLI. The result is MALABSORPTION, especially of fats, with fat excretion in the stools (STEATORRHOEA). The condition is also called ‘gluten-induced enteropathy’.
coeliac disease; gluten-sensitive enteropathy autoimmune-mediated, familial, genetic and environmental tendency to small-intestine inflammation due to gluten allergy, characterized by gluten (wheat) intolerance and resultant malabsorption of food; characterized by abdominal pain, chronic diarrhoea, weight loss and mouth ulcers; presents at any age, predominantly affecting females, atopic individuals, those with autoimmune disease (e.g. thyroid disease, type 1 diabetes mellitus, inflammatory bowel disease), chronic liver disease and fibrosing alveolitis; it characteristically causes dermatitis herpetiformis

ce·li·ac dis·ease

(sē'lē-ak di-zēz') [MIM*212750]
A disease occurring in children and adults characterized by sensitivity to gluten, with chronic inflammation and atrophy of the mucosa of the upper small intestine.
Synonym(s): gluten enteropathy, coeliac disease.
References in periodicals archive ?
In addition, the company will advance the development of its two products, including TolPlus, for Gluten Intolerance, forecast to reach the market in 2021.
However, because researchers haven't confirmed that symptoms of gluten intolerance are definitely linked to gluten, many health experts prefer the phrase "non-celiac wheat sensitivity" (NCWS).
This groundbreaking, authoritative guide is an invaluable roadmap for the newly diagnosed with gluten intolerance, for those already dealing with gluten-related issues, and for anyone who thinks they may have an issue with gluten.
In their article "Glyphosate, Pathways to Modern Diseases II: Celiac Sprue and Gluten Intolerance," Samsel and Seneff present numerous correlations between celiac disease and glyphosate's known effects.
In addition to the green and health-conscious nature of Organic Bakery's products, the brand offers gluten-free bread for people suffering from Celiac disease or gluten intolerance.
Combining personal accounts with exhaustive research, this outstanding book should become a definitive resource on gluten intolerance.
Cynthia Kupper, RD, Executive Director, Gluten Intolerance Group of North America.
Find Me Gluten Free is a free website and iPhone/Android app for those who follow a gluten-free lifestyle due to celiac disease, gluten intolerance or for a number of other dietary reasons.
I am willing to bet that we all know someone who is on - or who has tried - a gluten-free diet, for whatever reason, be it food allergies, gluten intolerance or just the perception that eating gluten-free offers a cleaner, better-for-you alternative.
Also known as gluten intolerance, celiac disease occurs when gluten--a protein in wheat, barley, and rye--damages the lining of the small intestine, causing a variety of symptoms.
Gluten intolerance is also known as "gluten sensitivity.