glutathione S-transferase

(redirected from Glutathione transferase)

glu·ta·thi·one S-·trans·fer·ase

a class of enzymes that catalyzes the reaction of glutathione with an acceptor molecule (for example, an arene oxide) to form an S-substituted glutathione; a key step in detoxification of many substances; start of the mercapturic acid pathway.
Synonym(s): ligandin
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References in periodicals archive ?
After the study was underway, a subgroup of mothers were genotyped for 2 nAChR and 3 glutathione transferase polymorphisms associated with smoking and lung disease.
33) have shown that glutathione transferase activity is critical for interpretation of DNA damage in maternal and newborn white blood cells after exposure to urban pollution.
DCA is primarily biotransformed to glyoxylate by the bifunctional enzyme glutathione transferase zetal and maleylacetoacetate isomerase (GSTzl/ MAAI), which also catalyzes the penultimate step in the phenylalanine and tyrosine catabolic pathway.
The hereditary transmission of high glutathione transferase activity towards trans-stilbene oxide in human mononuclear leukocytes.
Immunohistological analysis of glutathione transferase A4 distribution in several human tissues using a specific polyclonal antibody.
Identification of class-mu glutathione transferase genes GSTM1-GSTM5 on human chromosome lp13.
Microsomal glutathione transferase 1 (MGST1) is a representative of the superfamily of membrane proteins, which are termed membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG).
Functional divergence in the glutathione transferase superfamily in plants.