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glutathione synthetase

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glutathione synthetase /glu·ta·thi·one syn·the·tase/ (sin´thĕ-tās) a ligase catalyzing the formation of glutathione; deficient activity causes decreased levels of glutathione and increased levels of 5-oxoproline and cysteine. If confined to erythrocytes, the deficiency results in well-compensated hemolytic anemia; if generalized, metabolic acidosis and neurologic dysfunction may also occur.


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Whether or not up-regulation of activity of glutathione synthetase is done by AFE requires further study.
 
 
 
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