The patent mentions cannabidiol's ability as an antiepileptic, to lower intraocular pressure in the treatment of glaucoma, lack of toxicity or serious side effects in large acute doses, its neuroprotectant properties, its ability to prevent neurotoxicity mediated by NMDA, AMPA, or kainate receptors; its ability to attenuate glutamate toxicity
, its ability to protect against cellular damage, its ability to protect brains from ischemic damage, its anxiolytic effect, and its superior antioxidant activity which can be used in the prophylaxis and treatment of oxidation associated diseases.
Additional potential neuroprotective effects of curcumin and/or the curcuminoids include as an antidepressant; protection against aluminium induced neurotoxicity, ethanol-induced brain damage, sodium-arsenite toxicity, 3-nitorpropionic acid-induced toxicity, MPTP toxicity, traumatic brain injury, lead induced neurotoxicity, glutamate toxicity
and brain focel ischemia; memory improvement by HIV glycoprotein; anti aging; reversal of amyloid pathology and ethanol induced neurotoxicity; and restoration of the synaptic plasticity.
Glutamate is known to cause neuronal cell death via both glutamate receptor-mediated excitotoxicity and reactive oxygen species-mediated oxidative glutamate toxicity
(Satoh et al.
is a new mechanism of beta cell destruction not previously known, Drs.
Considered an initiator (8) Table 2: Comparison Between Contributing Factors and Initiators in ALS and MCS ALS MCS Glutamate Toxicity Glutamate Toxicity
Oxidative Stress Stress: Physical, Psychological, Emotional Trauma Mitochondrial Dysfunction Mitochondrial Dysfunction Autoimmune Disease Infectious Disease Viral, Bacterial, Parasitic, Fungal Infection Toxic Chemical Exposure Toxic Chemical Exposure Exposure to Heavy Metals Heavy Metal Toxicity Calcium and Magnesium Deficiency Nutrient Deficiencies Carbohydrate Metabolism Dysfunction Growth Factor Deficiency Hormone Disruption
NMDA receptor-mediated glutamate toxicity
of cultured cerebellar, cortical and mesen-cephalic neurons: Neuroprotective properties of amantadine and memantine.
com) announces updates to their Glutamate Toxicity
Glutamate is known to cause neuronal cell death through both glutamate receptor-mediated excitotoxicity and reactive oxygen species (ROS)-mediated oxidative glutamate toxicity
(Satoh et al.
Zinc is an important modifier of glutamate toxicity
, a neurotransmitter linked to cell death in ALS patients.
Dodecylglycerol provides partial protection against glutamate toxicity
in neuronal cultures derived from different regions of the embryonic rat brain.
In the next step of the experiment, BI-6C9 (an inhibitor of the pro-apoptotic BH-3 protein BID) was used to prevent glutamate toxicity
in HT-22 cells.
Previously, Guilford scientists reported that in a tissue culture model of ALS, NAALADase inhibitors could protect against chronic glutamate toxicity