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excitotoxicity |
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excitotoxicity exaggerated and continuous stimulation by a neurotransmitter, especially in those neuronal systems which use glutamate as the transmitter. excitotoxicity Neurology Neuronal injury caused by excessive release of excitatory neurotransmitters–glutamate and aspartate causing damage to nerve and glial cells, which occurs in diverse neurologic diseases that may be acute–eg
hypoglycemia, seizures, stroke, or trauma or chronic neurodegenerative disease–eg AIDS-dementia complex, amyotrophic lateral sclerosis, Huntington's disease, and possibly Alzheimer's disease How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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NMDA receptor-mediated glutamate toxicity of cultured cerebellar, cortical and mesen-cephalic neurons: Neuroprotective properties of a unique class of compounds discovered by Zeneca that inhibit glutamate toxicity without interacting with the glutamate site or calcium channels. |
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