excitotoxicity

(redirected from Glutamate neurotoxicity)
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excitotoxicity

(ek-sī'tō-tok-sis'i-tē),
Neuronal death resulting from increased intracellular glutamate; neuronal ischemia leads to ATP loss and depolarization, with glutamate release from synapses, and subsequent overstimulation leading to sodium and calcium ion gate porosity.

excitotoxicity

Neurology Neuronal injury caused by excessive release of excitatory neurotransmitters–glutamate and aspartate causing damage to nerve and glial cells, which occurs in diverse neurologic diseases that may be acute–eg hypoglycemia, seizures, stroke, or trauma or chronic neurodegenerative disease–eg AIDS-dementia complex, amyotrophic lateral sclerosis, Huntington's disease, and possibly Alzheimer's disease

excitotoxicity

exaggerated and continuous stimulation by a neurotransmitter, especially in those neuronal systems which use glutamate as the transmitter.
References in periodicals archive ?
Glutamate neurotoxicity in the cochlea: A possible consequence of ischaemic or anoxic conditions occurring in ageing.
Pharmaceuticals of Germany and the University of Arizona, Tucson, suggest memantine protects neurons from glutamate neurotoxicity.
bizarre movements and mental deterioration), and suggests that glutamate neurotoxicity may be involved in the cause of this disease.
This discovery provides us with an interesting new biological target for drug development, since small molecule inhibitors of serine racemase could be anticipated to prevent glutamate neurotoxicity in conditions like stroke and other neurodegenerative conditions," continued Dr.
36,397), contains additional important claims relating to the use of PARP inhibitors for the prevention of glutamate neurotoxicity.

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