Nasrallah said, are impairment of antiapoptotic signaling, glutamate excitotoxicity
, hypercortisolemia, and gamma-aminobutyric acid hypofunction.
This antibiotic has been studied extensively as an adjunctive treatment in schizophrenia and has proven to have several neuroprotective effects including anti-inflammatory, anti-oxidant, and anti-apoptotic, and reduces glutamate excitotoxicity
The protective effects of L-theanine have been shown in animal models for at least the first three of these disorders, suggesting that regular L-theanine supplementation might be important in fending off these tragic conditions by opposing the destructive effects of long-term glutamate excitotoxicity
Lithium protection against glutamate excitotoxicity
in rat cerebral cortical neurons: involvement of NMDA receptor inhibition possibly by decreasing NR2B tyrosine phosphorylation.
is the pathological process by which neuronal cells are damaged or killed by excess glutamate receptor activation.
Effects of vitamin E in preserving mitochondrial membrane potential of astrocytes after glutamate excitotoxicity
and oxidative stress have been suggested as one of the important pathophysiological mechanisms in glaucomatous neurodegeneration [74, 75].
N-methyl-D-aspartate receptors (NMDARs) play a key role in mediating glutamate excitotoxicity
because their high calcium permeability (Hardingham and Bading 2003).
The glutamate generated from pyruvate can produce glutamate excitotoxicity
and neuronal degeneration.
During their study, the researchers discovered a common variant in the GRM7 gene, which the research team believes may be associated with susceptibility to glutamate excitotoxicity
and hearing loss.
Viral-induced spinal motor neuron death is non-cellautonomous and involves glutamate excitotoxicity
Studies have indicated that glutamate excitotoxicity
occurs in the cochlea under pathologic conditions, such as noise trauma and ischemia.