GLUD1

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GLUD1

A gene on chromosome 10q23.3 that encodes glutamate dehydrogenase 1, a mitochondrial matrix enzyme which catalyses the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. It plays a key role in regulating amino acid-induced insulin secretion. GLUD1 is allosterically activated by ADP and inhibited by GTP and ATP; it may be involved in learning and memory by increasing the turnover of the neurotransmitter glutamate.

Molecular pathology
Missense mutations of GLUD1 cause hyperinsulinemic hypoglycaemia type 6.
References in periodicals archive ?
Evaluation of a simultaneous detection kit for the glutamate dehydrogenase antigen and toxin A/B in feces for diagnosis of Clostridium difficile infection.
Glutamate Dehydrogenase International and China Market Analysis
An evaluation of tests for faecal toxin, glutamate dehydrogenase, lactoferrin and toxigenic culture in the diagnostic laboratory.
The glutamate dehydrogenase generated ammonia can stimulate both the GABA and NMDA receptor acting as a gasotransmitter.
Is a two-step glutamate dehydrogenase antigen-cytotoxicity neutralization assay algorithm superior to the premier toxin A and B enzyme immunoassay for laboratory detection of Clostridium difficile?
Glutamate dehydrogenase HI is the second most common form of HI.
The glutamate dehydrogenase (GDH)-based biotechnology [7, 8] for determining the mineral nutrient requirements of crops could provide the approach for enhancing the fat and cellulosic biomass yields of peanut.
Ammonia is measured using alpha ketoglutarate catalyzed by glutamate dehydrogenase to yield glutamate with the oxidation of NADPH to NADP.
To determine if a similar approach can be used in Homarus americanus, activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), glutamate dehydrogenase (GD), sorbitol dehydrogenase (SDH), amylase (AMY) and lipase (LIP) were measured in tissue homogenates of heart, hepatopancreas, abdominal muscle, proximal intestine, antennal gland, hemocyte lysate supernatant and hemolymph plasma and serum.
Following are the differences between the aca and Determiner methods: (a) source of glutamate dehydrogenase, bovine liver vs yeast; (b) pH of assay buffer, pH 7.

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