GLUD1

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GLUD1

A gene on chromosome 10q23.3 that encodes glutamate dehydrogenase 1, a mitochondrial matrix enzyme which catalyses the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. It plays a key role in regulating amino acid-induced insulin secretion. GLUD1 is allosterically activated by ADP and inhibited by GTP and ATP; it may be involved in learning and memory by increasing the turnover of the neurotransmitter glutamate.

Molecular pathology
Missense mutations of GLUD1 cause hyperinsulinemic hypoglycaemia type 6.
References in periodicals archive ?
In addition, low temperature can reduce plant nitrogen (N) uptake capacity and the activity of enzyme in N metabolism, such as glutamate dehydrogenase (GDH) (Lu et al.
Evaluation of a simultaneous detection kit for the glutamate dehydrogenase antigen and toxin A/B in feces for diagnosis of Clostridium difficile infection.
Smith, TJ and Stanley, CA, "Untangling the glutamate dehydrogenase allosteric nightmare", Trends in Biochemical Sciences 2008; 33: 557-564.
difficile tcdB, and a glutamate dehydrogenase detection assay to cytotoxin testing and cytotoxigenic culture methods.
The ammonia generated by the action of glutamate dehydrogenase has got multiple actions.
Molecular identification of Giardia duodenalis isolates from humans, dogs, cats and cattle from the state of Sao Paulo, Brazil, by sequence analysis of fragments of glutamate dehydrogenase (gdh) coding gene.
Some aminotransferases, like alanine and aspartate aminotransferase and glutamate dehydrogenase are the main enzymes used to verify amino acid oxidation fluxes from protein catabolism.
The activity levels of Glutamate Dehydrogenase was estimated by the method of Nachlar et al.

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