glutamate decarboxylase(redirected from Glutamate decarboxylate-1)
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glu·ta·mate de·car·box·yl·ase (GAD),
a carboxy-lyase converting l-glutamate to 4-aminobutyrate and CO2 as well as l-aspartate to 3-aminopropanoate and CO2; a defect in the binding of this protein's coenzyme is believed to cause pyridoxine dependency with seizures.
Synonym(s): aspartate 1-decarboxylase
GLULAn intronless gene on chromosome 1q31 that encodes a glutamine synthetase, which catalyses the synthesis of glutamine from glutamate and ammonia. Glutamine is a key source of energy and is involved in cell proliferation, inhibition of apoptosis, and cell signalling. GLUL is expressed during early foetal stages, and plays an important role in controlling pH by removing ammonia from circulation.
GLUL mutations are associated with congenital glutamine deficiency.