glutamate decarboxylase

Also found in: Wikipedia.

glu·ta·mate de·car·box·yl·ase (GAD),

a carboxy-lyase converting l-glutamate to 4-aminobutyrate and CO2 as well as l-aspartate to 3-aminopropanoate and CO2; a defect in the binding of this protein's coenzyme is believed to cause pyridoxine dependency with seizures.


An intronless gene on chromosome 1q31 that encodes a glutamine synthetase, which catalyses the synthesis of glutamine from glutamate and ammonia. Glutamine is a key source of energy and is involved in cell proliferation, inhibition of apoptosis, and cell signalling. GLUL is expressed during early foetal stages, and plays an important role in controlling pH by removing ammonia from circulation.

Molecular pathology
GLUL mutations are associated with congenital glutamine deficiency.
References in periodicals archive ?
Los genes de interes evaluados para este estudio fueron: Aminomethyltransferase, Glycine dehydrogenase, Glycine hydroxymethyltransferase, [DELTA]-1-pyrroline-5-carboxylate synthase, Ornithine aminotransferase, Arginase, Alanine transaminase, Alanine-glyoxylate transaminase, Glutamate decarboxylase, Glutamate decarboxylase 1-2, Spermidine synthase, Aldehyde dehydrogenase, ATP-grasp domain-containing protein, Cysteine sulfinic acid decarboxylase1-2, Taurine transporter, HSP beta 1, Sodium- and chloride-dependent glycine transporter (Meng et al.
Producing alkaline GABA and cadaverine, both glutamate decarboxylase and lysine decarboxylase enzymes have strategic role in neutralizing acidic condition.
Lab analysis of metagenomic DNA sequencing data allowed us to demonstrate that microbial glutamate decarboxylase encoding gene is very abundant in intestinal microbiota as compared to other body sites," Pokusaeva said.
The main inhibitory mediator in the brain, gamma amino butyric Acid (GABA), is formed from glutamate (excitatory) by the enzyme glutamate decarboxylase (GAD).
Rapid determination of glutamate decarboxylase activity from lactic acid bacteria by spectrometric method and its applications.
Glutamate decarboxylase (GAD) is the unique enzyme to catalyze the conversion of L-glutamate or its salts to GABA through the single-step a-decarboxylation [14,15].
The glutamate decarboxylase gene and associated metabolites (GABA and glutamic acid) are up-regulated in response to infection in both types of rice, and the glutathione transferase gene and its metabolite (oxidized glutathione) are differentially regulated between the wild-type and the transgenic strains.
Cell origin was confirmed by the presence of mRNA transcripts for: calcium/calm odulin-dependent protein kinase-II (CamK-II) for excitatory pyramidal cells, glutamate decarboxylase (GAD65) for inhibitory interneurons and glial fibrillary acidic protein (GFAP) for astrocytic cells (see Figure).
GABA is synthesized in a reaction catalyzed by the calmodulin modulated enzyme glutamate decarboxylase (GAD) that is activated, in part, by stress-induced increases in [Ca.
Sex steroid regulation of glutamate decarboxylase mRNA expression in goldfish brain is sexually dimorphic.
Two islet autoantibody specificities definitely represent major subfractions of ICAs: antibodies to the 65-kDa isoform of glutamic acid decarboxylase (GAD65-abs) (7, 8) the [gamma]-aminobutyric acid-synthesizing isoform of glutamate decarboxylase in human islets (9), and antibodies to islet antigen-2 (IA2-abs) (10), a protein tyrosine phosphatase expressed in islet cells that has been described as a membrane protein composed of 979 amino acids (11).
When the mice reached about 4 weeks of age, both terms observed that glutamate decarboxylase (GAD) began activating T-cells.

Full browser ?