metformin

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metformin

 [met-for´min]
a hypoglycemic agent that potentiates the action of insulin; used in treatment of type 2 diabetes mellitus.

metformin

/met·for·min/ (met-for´min) an antihyperglycemic agent that potentiates the action of insulin, used in the treatment of type 2 diabetes mellitus.

metformin

(mĕt-fôr′mĭn)
n.
An oral hypoglycemic drug, C4H11N5, usually used in its hydrochloride form, that decreases glucose production by the liver and increases peripheral glucose uptake, used to treat type 2 diabetes.

metformin

[met-for′min]
a hypoglycemic agent that potentiates the action of insulin, used in treatment of type 2 diabetes mellitus.

metformin

A biguanide antihyperglycaemic and antidiabetic used for type-2 diabetes, alone or with sulfonurea. Metformin sensitises cells to insulin, decreases serum glucose and insulin, decreases insulin resistance, increases glucose utilisation, decreases triglycerides, and reduces weight; in some patients, it suppresses appetite.

Adverse effects
GI tract complaints—e.g., diarrhoea, nausea, vomiting, bloating—occur in 30%.
 
Contraindications
Metabolic acidosis, liver disease; metformin has an equal and additive effect with troglitazone, which acts by increased peripheral glucose disposal.

metformin

Glucophage® Diabetology A biguanide antihyperglycemic and antidiabetic used for type 2 DM, alone or with sulfonurea; metformin sensitizes cells to insulin, ↓ serum glucose and insulin, ↓ insulin resistance, ↑ glucose utilization, ↓ TGs, ↓ weight; in some Pts, it suppresses appetite. See Diabetes mellitus. Cf Troglitazone.

metformin

A biguanide oral HYPOGLYCAEMIC drug used in the treatment of MATURITY ONSET DIABETES. The drug may be dangerous to those with liver or kidney disease or a high alcohol intake. The drug is on the WHO official list. A brand name is Glucophage.

metformin

biguanide agent used to treat diabetes mellitus; in presence of insulin, it decreases hepatic gluconeogenesis and increases peripheral uptake of glucose (i.e. it decreases peripheral insulin resistance); it is used to treat type 2 diabetes in cases that retain some endogenous pancreatic function, obese diabetics, and those whose blood glucose levels are not adequately controlled by sulphonylureas alone; also used in conjunction with sulphonylureas or acarbose or injected insulin or a glitazone or repaglinide; also used to treat some type 1 diabetics where it is used as an adjunct to parenteral (administered) insulin; may be used to treat polycystic ovary disease (these patients typically show insulin resistance, even though not frankly diabetic)

metformin

a biguanide used in the management of diabetes in cats. It acts by inhibiting gluconeogenesis, stimulation of peripheral glycolysis and inhibiting intestinal absorption of carbohydrates.

Patient discussion about metformin

Q. does anyone have experience switching from metformin to janumet?

A. ?
Janumet is metformin... it's a generic name for it. metformin is a substance name and there's all kind of drug companies that manufacture it (all in different names and little formula differences).

Q. I'm a diabetic and have been on metformin for aprox. 4 yrs. The Dr. upped my dose and my sugar levels went way up. I stopped taking it and for the last two days sugar levels have stayed between 115 and 135. Whereas, with the higher dose of metformin. It reached 269. Diet is the same. What is going on. And do I trust my Dr. evaluation.

A. I doubt the cause of the sugar rise has any relation to the Metformin increased dosage. It could be your body has stopped reacting to Metformin- that happens to almsot all patients with diabetes after a while, and a combination treatment with another drug or a change in drugs is performed. You should remain on the new dosage for another week or two, and keep track of your sugar level meanwhile, and if things don't improve then you should see your doctor again so that he/she will make a new evaluation.

More discussions about metformin
References in periodicals archive ?
As a result of this arrangement, PDL has weekly visibility into the Depomed royalties that have been paid and is in constant communication with Depomed on all of the royalties due under the agreement, including Glumetza.
When PDL did not receive reports and payments for July and August 2015 for Glumetza, Depomed contacted Valeant to request the contractually required reports and to inquire when payment would be made.
The number of patients with at least one GI adverse event (abdominal pain, diarrhea, GI upset, and nausea) was lower with GLUMETZA than with previous metformin formulations (38% vs.
We believe that by allowing patients to tolerate higher doses of metformin, GLUMETZA may play an important role in helping more patients remain on metformin therapy.
8 million in net sales of GLUMETZA for the month of September under the new commercialization agreement.
0 million for the third quarter of 2011 was based on GLUMETZA net sales recorded by Depomed for July and August 2011.
In addition, Santarus will reimburse Depomed for 70% of its future costs in ongoing Paragraph IV litigation for GLUMETZA.
After promoting GLUMETZA for almost three years, our commercial organization is eager to manage contracting and pricing to maximize the potential for the brand.
Promotion revenue for the first quarter of 2011 associated with GLUMETZA was $10.
License fee expenses to include a sales milestone of $3 million payable to Depomed if annual GLUMETZA net product sales exceed $80 million during the calendar year.
0 million in March 2011 based on achievement of GLUMETZA net product sales that exceeded $50.
Product-related revenue for 2010 was negatively impacted by the mid-year availability of generic versions of ZEGERID Capsules and Depomed's voluntary recall and related suspension of GLUMETZA 500 mg product shipments from June 2010 through early January 2011.