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Some exotic parasites have already been discovered as a result of their significant population effects, such as, for example, the European protozoan Glugea hertwigi, which caused high-rate die-offs of the rainbow smelt in Lake Erie and Lake Ontario during the 1960s and 1970s (Nepszy et al.
Mortality of young-of-the-year rainbow smelt (Osmerus mordax) in Lake Erie associated with the occurrence of Glugea hertwigi.