To prevent unconjugated bilirubin being deposited in tissues it is bound to albumin (a protein) and then transported in the blood to the liver where it is converted to its conjugated form by an enzyme called glucuronyltransferase
(England, 2010; McIntosh and Stenson, 2008).
A stepwise addition of D-glucuronic acid from UDP-D-glucuronic acid to bilirubin, takes place with the help of the enzyme UDP-glucuronate-bilirubin glucuronyltransferase
This entry of bilirubin into liver cells is enabled by an enzyme called glucuronyltransferase
Fogelfeld L, Sarova-Pinchas I, Meytes D, et al: Phosphofructokinase deficiency (Tarui disease) associated with hepatic glucuronyltransferase
deficiency (Gilbert's syndrome): a case and family study.
Although how TCS disrupts thyroid hormones is still unclear, our findings are biologically plausible based on evidence from animal studies concluding that TCS had the potential to influence thyroid function by changing the activity of glucuronyltransferase
in Phase II (the reaction of conjugations) in the liver (Schuur et al.
Sampeitro M, Lupica L, Perrero L, et al: The expression of uridine diphosphate glucuronyltransferase
gene is a major determinant of bilirubin level in heterozygous [beta] thalassemia and in G6PD deficiency.
Gilbert syndrome is an inborn error of bilirubin conjugation caused by mutations in the conjugating enzyme uridine diphosphate glucuronyltransferase
DLCs, including some PCB congeners, bind to the aryl hydrocarbon receptor (AhR) and activate the hepatic uridine diphosphate glucuronyltransferase
(UDP-GT) enzymes responsible for [T.
Anti-microsomal antibodies targeting P450IA2 and P450IIIAl isoenzymes have also been reported in idiosyncratic liver injuries associated with dihydralazine and aromatic anticonvulsants, as well as anti-LKM3 antibodies directed against uridine diphosphate glucuronyltransferase
(UDPGT) enzymes [24-26].
4] metabolism by the induced glucuronyltransferase
More than 90% of acetaminophen, taken in therapeutic doses, is metabolised in the liver to phenolic glucuronide and sulfate by glucuronyltransferases
and sulfotransferases and is subsequently excreted in the urine.
DHMA and HMMA can be further conjugated by uridine diphosphate glucuronyltransferases
(UGTs) to DHMA 3-glucuronide, DHMA 4-glucuronide, and HMMA glucuronide or by sulfotransferases to DHMA 3-sulfate, DHMA 4-sulfate, and HMMA sulfate.