Detox mechanisms include acetylation, sulfating, glucuronidation
, and oxidation.
Direct analysis of intact conjugates was a prerequisite for assessing the impact of glucuronidation
and sulfation of MDMA's phase I metabolites.
Lamotrigine is metabolized via glucuronidation
and eliminated renally.
Vorinostat, a pan-HDACi, undergoes glucuronidation
17[alpha]-Ethinylestradiol is mainly metabolized via intestinal and hepatic oxidation (CYP3A4), glucuronidation
(UGT1A1) and sulfation (SULTs) (Zhang et al.
0 in both matrices on several occasions, indicating extensive ester-linked glucuronidation
Although both adult rodents and primates use glucuronidation
of BPA through uridine 5 '-diphospho-glucuronosyltransferases as part of their phase II metabolism system, the primary mechanism through which BPA is cleared from blood differs, with urinary excretion being the primary route in primates versus the biliary--fecal route in rodents (Inoue et al.
BPA is metabolized in the liver by the CYP450 enzymes, and methylation and glucuronidation
Metabolism creates about 40 metabolites via multiple metabolic pathways; the main ones are glucuronidation
by UGT1A4 and oxidative metabolism by cytochrome P450 (CYP)1A2.
The reactions examined here include methylation, sulfation, glucuronidation
, acetylation, conjugation with glutathione, while there is also a rigorous presentation of the pivotal role of xenobiotic-coenzyme A conjugates as a crossroads to various metabolic reactions.
In pharmacokinetic aspect, VPA is metabolized primarily by direct glucuronidation
to form the acyl glucuronide (VPA-G) and also by [beta]-oxidation (Davis et al.
UDP-glucuronosyltransferases (UGTs)  are important enzymes involved in the glucuronidation
of diverse exogenous and endogenous compounds.