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glucuronidation

   Also found in: Wikipedia 0.06 sec.
glucuronidation (glōō·k·rō·n·dāˑ·shn),
n a phase II detoxification pathway occurring in the liver in which glucuronic acid is conjugated with toxins. Effectively detoxifies the majority of commonly prescribed drugs.


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Further, xenobiotics can induce steroid-metabolizing enzymes, including steroid sulfotransferases, steroid glucuronidation enzymes, and steroid hydroxylases (You 2004).
Antiestrogens inhibit xenoestrogen-induced brain aromatase activity ... by Brouwer, Marius / Environmental Health Perspectives
Coadministration of gemfibrozil (600 mg twice daily for 3 days) with simvastatin (40 mg daily) resulted in clinically significant increases in simvastatin acid AUC (185%) and Cmax (112%), possibly due to inhibition of simvastatin acid glucuronidation by gemfibrozil (see WARNINGS, Myopathy/Rhabdomyolysis, PRECAUTIONS, Drug Interactions, DOSAGE AND ADMINISTRATION).
Data Recently Published in Mayo Clinic Proceedings Showed VYTORIN(R) ... by Business Wire
Glucuronidation patterns of common urinary and serum monoester phthalate metabolites.
Human breast milk contamination with phthalates and alterations of ... by Skakkebaek, Niels E. / Environmental Health Perspectives
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