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glucose-6-phosphate dehydrogenase |
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glucose-6-phosphate dehydrogenase /glu·cose-6-phos·phate de·hy·dro·gen·ase/ (G6PD) (-fos´fāt de-hi´dro-jen-ās) an enzyme of the pentose phosphate pathway which, with NADP+ as coenzyme, catalyzes the oxidation of glucose 6-phosphate to a lactone. Deficiency of the enzyme causes severe hemolytic anemia.
dehydrogenase an enzyme that mobilizes the hydrogen of a substrate so that it can pass to a hydrogen acceptor, such as NAD+ or FAD+. alcohol dehydrogenase dimeric enzyme protein of the liver catalyzing the NAD+-linked dehydrogenation of ethanol to acetaldehyde. glucose-6-phosphate dehydrogenase see glucose-6-phosphate dehydrogenase. glutamate dehydrogenase (GD), glutamic dehydrogenase an enzyme that catalyzes the reversible reaction of glutamic acid into 2-oxoglutaric acid and ammonia. High concentrations occur in the liver of sheep, cattle, horses and dogs. Serum levels are useful in detecting hepatocellular damage in ruminants. l-iditol dehydrogenase (ID) a liver specific enzyme; serum determinations have been used in the horse to detect hepatocellular damage. Called also sorbitol dehydrogenase, SDH. isocitrate dehydrogenase (ICD) an enzyme found in high concentrations in many tissues. Two major forms of the enzyme, an NAD+-dependent ICD associated with the mitochondrial TCA cycle and a NADP+-dependent ICD associated with fat synthesis in adipose tissue and lactating mammary gland of ruminants or with steroidogenesis in endocrine tissues. Serum levels have been used to detect hepatocellular damage, but it is not highly specific. lactate dehydrogenase (LDH), lactic acid dehydrogenase an enzyme that catalyzes the interconversion of lactate and pyruvate. It is widespread in tissues and is particularly abundant in kidney, skeletal muscle, liver and myocardium. It appears in elevated concentrations when these tissues are injured. See also mouse lactic dehydrogenase elevating virus. lactate dehydrogenase agent see pestivirus. polyol dehydrogenase see l-iditol dehydrogenase (above). sorbitol dehydrogenase (SDH) see l-iditol dehydrogenase (above). How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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1996), interfere with the activity of key antioxidant enzymes such as glutathione reductase, glutathione S-transferase, glutathione peroxidase, and glucose 6-phosphate dehydrogenase (Maiti and Chatterjee 2000; Santra et al. Class II contains Primaquine, a drug that targets both the initial liver stage of all four species, as well as the hypnozoite form of vivax and ovale and the erythrocytic stage of vivax, but cannot be given to patients with the glucose 6-phosphate dehydrogenase (G-6-PD) deficiency. Studies to rule out underlying immunodeficiency showed no evidence of glucose 6-phosphate dehydrogenase (G6PD) deficiency or HIV infection. |
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