metformin

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metformin

 [met-for´min]
a hypoglycemic agent that potentiates the action of insulin; used in treatment of type 2 diabetes mellitus.

metformin

/met·for·min/ (met-for´min) an antihyperglycemic agent that potentiates the action of insulin, used in the treatment of type 2 diabetes mellitus.

metformin

(mĕt-fôr′mĭn)
n.
An oral hypoglycemic drug, C4H11N5, usually used in its hydrochloride form, that decreases glucose production by the liver and increases peripheral glucose uptake, used to treat type 2 diabetes.

metformin

[met-for′min]
a hypoglycemic agent that potentiates the action of insulin, used in treatment of type 2 diabetes mellitus.

metformin

A biguanide antihyperglycaemic and antidiabetic used for type-2 diabetes, alone or with sulfonurea. Metformin sensitises cells to insulin, decreases serum glucose and insulin, decreases insulin resistance, increases glucose utilisation, decreases triglycerides, and reduces weight; in some patients, it suppresses appetite.

Adverse effects
GI tract complaints—e.g., diarrhoea, nausea, vomiting, bloating—occur in 30%.
 
Contraindications
Metabolic acidosis, liver disease; metformin has an equal and additive effect with troglitazone, which acts by increased peripheral glucose disposal.

metformin

Glucophage® Diabetology A biguanide antihyperglycemic and antidiabetic used for type 2 DM, alone or with sulfonurea; metformin sensitizes cells to insulin, ↓ serum glucose and insulin, ↓ insulin resistance, ↑ glucose utilization, ↓ TGs, ↓ weight; in some Pts, it suppresses appetite. See Diabetes mellitus. Cf Troglitazone.

metformin

A biguanide oral HYPOGLYCAEMIC drug used in the treatment of MATURITY ONSET DIABETES. The drug may be dangerous to those with liver or kidney disease or a high alcohol intake. The drug is on the WHO official list. A brand name is Glucophage.

metformin

biguanide agent used to treat diabetes mellitus; in presence of insulin, it decreases hepatic gluconeogenesis and increases peripheral uptake of glucose (i.e. it decreases peripheral insulin resistance); it is used to treat type 2 diabetes in cases that retain some endogenous pancreatic function, obese diabetics, and those whose blood glucose levels are not adequately controlled by sulphonylureas alone; also used in conjunction with sulphonylureas or acarbose or injected insulin or a glitazone or repaglinide; also used to treat some type 1 diabetics where it is used as an adjunct to parenteral (administered) insulin; may be used to treat polycystic ovary disease (these patients typically show insulin resistance, even though not frankly diabetic)

metformin

a biguanide used in the management of diabetes in cats. It acts by inhibiting gluconeogenesis, stimulation of peripheral glycolysis and inhibiting intestinal absorption of carbohydrates.

Patient discussion about metformin

Q. does anyone have experience switching from metformin to janumet?

A. ?
Janumet is metformin... it's a generic name for it. metformin is a substance name and there's all kind of drug companies that manufacture it (all in different names and little formula differences).

Q. I'm a diabetic and have been on metformin for aprox. 4 yrs. The Dr. upped my dose and my sugar levels went way up. I stopped taking it and for the last two days sugar levels have stayed between 115 and 135. Whereas, with the higher dose of metformin. It reached 269. Diet is the same. What is going on. And do I trust my Dr. evaluation.

A. I doubt the cause of the sugar rise has any relation to the Metformin increased dosage. It could be your body has stopped reacting to Metformin- that happens to almsot all patients with diabetes after a while, and a combination treatment with another drug or a change in drugs is performed. You should remain on the new dosage for another week or two, and keep track of your sugar level meanwhile, and if things don't improve then you should see your doctor again so that he/she will make a new evaluation.

More discussions about metformin
References in periodicals archive ?
In clinical trials with more than 1,200 patients, Glucophage XR was shown to be comparable to Glucophage in lowering patients' blood sugar levels.
The study evaluated the dissolution rates of Glucophage XR compared to six generic manufacturers in an assay performed with modified simulated gastric fluid.
Glucophage XR (metformin hydrochloride extended-release tablets), as a monotherapy, is indicated as an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes in patients 17 years of age and older.
sales for Glucophage XR were over $453 million for the twelve months ending June 2003.
In 2002, sales of Glucophage XR (extended release metformin) were approximately $450 million, and the total diabetes market is estimated at more than $8 billion.
Accupril, Actosm, Advair Disku, Allegra-D, Alphagan-P, Aricept, Arimidex, Avalide, Avandia,Avapro, Casodex, Celexa, Clarinex, Coumadin, Cozaar, Depakote, Detrol LA, Diovan, Exelon, Flonase, Flovent, Fosamax, Glucophage XR, Hyzaar, Lamictal, Lipitor, Mirapex, Mobic, Nasonex, Neurontin, Paxil, Pravachol, Premarin, Prempro, Prevacid, Prograf, Proscar, Risperdal, Serevent, Singulair, Synthroid, Topamax, Vioxx, Xalatan, Zocor and Zyrtec -- should be particularly alert to the potential for manufacturer-created shortages.
The prescription medications encompassed in the RFA "Canadian Drug Savings Calculator" are Accupril, Actosm, Advair Disku, Allegra-D, Alphagan-P, Aricept, Arimidex, Avalide, Avandia, Avapro, Casodex, Celexa, Clarinex, Coumadin, Cozaar, Depakote, Detrol LA, Diovan, Exelon, Flonase, Flovent, Fosamax, Glucophage XR, Hyzaar, Lamictal, Lipitor, Mirapex, Mobic, Nasonex, Neurontin, Paxil, Pravachol, Premarin, Prempro, Prevacid, Prograf, Proscar, Risperdal, Serevent, Singulair, Synthroid, Topamax, Vioxx, Xalatan, Zocor and Zyrtec.
On October 31, 2003 the Company announced that it had received a tentative approval for its generic version of Bristol-Myers Squibb's Glucophage XR (Metformin Hydrochloride extended- release tablets) 500 mg Tablet and that the Company anticipated launching its generic product following the expiration of another company's 180-day generic exclusivity period under the provisions of Hatch-Waxman.
The prescription medications encompassed in the RFA "Canadian Drug Savings Calculator" are Accupril, Actosm, Advair Disku, Allegra-D, Alphagan-P, Aricept, Arimidex, Avalide, Avandia,Avapro, Casodex, Celexa, Clarinex, Coumadin, Cozaar, Depakote, Detrol LA, Diovan, Exelon, Flonase, Flovent, Fosamax, Glucophage XR, Hyzaar, Lamictal, Lipitor, Mirapex, Mobic, Nasonex, Neurontin, Paxil, Pravachol, Premarin, Prempro, Prevacid, Prograf, Proscar, Risperdal, Serevent, Singulair, Synthroid, Topamax, Vioxx, Xalatan, Zocor and Zyrtec.
Glucophage XR was launched in the fourth quarter of 2000, and its first full year sales in 2001 were $223 million, with $90 million of those sales in the fourth quarter of the year.
We believe the exclusivity period for Glucophage XR expires at the end of 2003, and we look forward to launching our product at that time.