metformin

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metformin

 [met-for´min]
a hypoglycemic agent that potentiates the action of insulin; used in treatment of type 2 diabetes mellitus.

metformin

/met·for·min/ (met-for´min) an antihyperglycemic agent that potentiates the action of insulin, used in the treatment of type 2 diabetes mellitus.

metformin

(mĕt-fôr′mĭn)
n.
An oral hypoglycemic drug, C4H11N5, usually used in its hydrochloride form, that decreases glucose production by the liver and increases peripheral glucose uptake, used to treat type 2 diabetes.

metformin

[met-for′min]
a hypoglycemic agent that potentiates the action of insulin, used in treatment of type 2 diabetes mellitus.

metformin

A biguanide antihyperglycaemic and antidiabetic used for type-2 diabetes, alone or with sulfonurea. Metformin sensitises cells to insulin, decreases serum glucose and insulin, decreases insulin resistance, increases glucose utilisation, decreases triglycerides, and reduces weight; in some patients, it suppresses appetite.

Adverse effects
GI tract complaints—e.g., diarrhoea, nausea, vomiting, bloating—occur in 30%.
 
Contraindications
Metabolic acidosis, liver disease; metformin has an equal and additive effect with troglitazone, which acts by increased peripheral glucose disposal.

metformin

Glucophage® Diabetology A biguanide antihyperglycemic and antidiabetic used for type 2 DM, alone or with sulfonurea; metformin sensitizes cells to insulin, ↓ serum glucose and insulin, ↓ insulin resistance, ↑ glucose utilization, ↓ TGs, ↓ weight; in some Pts, it suppresses appetite. See Diabetes mellitus. Cf Troglitazone.

metformin

A biguanide oral HYPOGLYCAEMIC drug used in the treatment of MATURITY ONSET DIABETES. The drug may be dangerous to those with liver or kidney disease or a high alcohol intake. The drug is on the WHO official list. A brand name is Glucophage.

metformin

a biguanide used in the management of diabetes in cats. It acts by inhibiting gluconeogenesis, stimulation of peripheral glycolysis and inhibiting intestinal absorption of carbohydrates.

Patient discussion about metformin

Q. does anyone have experience switching from metformin to janumet?

A. ?
Janumet is metformin... it's a generic name for it. metformin is a substance name and there's all kind of drug companies that manufacture it (all in different names and little formula differences).

Q. I'm a diabetic and have been on metformin for aprox. 4 yrs. The Dr. upped my dose and my sugar levels went way up. I stopped taking it and for the last two days sugar levels have stayed between 115 and 135. Whereas, with the higher dose of metformin. It reached 269. Diet is the same. What is going on. And do I trust my Dr. evaluation.

A. I doubt the cause of the sugar rise has any relation to the Metformin increased dosage. It could be your body has stopped reacting to Metformin- that happens to almsot all patients with diabetes after a while, and a combination treatment with another drug or a change in drugs is performed. You should remain on the new dosage for another week or two, and keep track of your sugar level meanwhile, and if things don't improve then you should see your doctor again so that he/she will make a new evaluation.

More discussions about metformin
References in periodicals archive ?
According to the company, Glucophage XR and the drug active metformin are indicated for use in the management of type 2 diabetes treatment.
In clinical trials with more than 1,200 patients, Glucophage XR was shown to be comparable to Glucophage in lowering patients' blood sugar levels.
The company will continue to aggressively seek sales increases for such key brands as Plavix, Pravachol, Glucovance, Glucophage XR and Avapro.
Throughout this month the company has taken out full-page newspaper advertisements with coupons for a free month's supply of Glucophage XR, the once-a-day version of Glucophage, which the company says is the top-selling Type 2 diabetes pill in the country.
received Food and Drug Administration approval for Glucophage XR, a once-daily version of Glucophage, its blockbuster Type 2 diabetes treatment.