NR3C1

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NR3C1

A gene on chromosome 5q31.3 that encodes a glucocorticoid receptor, which acts as either a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, or as a regulator of other transcription factors.

Molecular pathology
NR3C1 mutation are associated with generalised glucocorticoid resistance.
References in periodicals archive ?
They pinpointed the glucocorticoid receptor pathway as being significantly associated both with development and with exposure to arsenic, cadmium, mercury, and selenium.
Glucocorticoid receptor phosphorylation at ser211 was also elevated following GA and 18[beta]GA treatment.
Cortisol binds to glucocorticoid receptors (GRs) that are made up of two identical subunits (i.
A second type of compound that has been developed--nitric oxide glucocorticoids or nitrosteroids--not only bind to the glucocorticoid receptor but also slowly release nitric oxide, resulting in synergistic anti-inflammatory effects.
2: two in the glucocorticoid receptor gene (GR/NR3C1, rs258747 and rs1866388) and one in the estrogen receptor-[alpha] gene (ESR1, rs12212176), all of them for G2 pubertal onset (Figure 1).
Glucocorticoid receptor activation selectively hampers N-methyl-o-aspartate receptor dependent hippocampal synaptic plasticity in vitro.
Oxidative stress and the glucocorticoid receptor (GR) expression decreasing have also been shown to play important roles in the occurrence of tissue injuries in endotoxic shock (Ho et al.
Glucocorticoid receptor gene variant in the 3' untranslated region is associated with multiple measures of blood pressure.
Glucocorticoids are a class of steroid hormones that bind to the glucocorticoid receptor present in almost every vertebrate animal cell.
To verify the possible involvement of glucocorticoid receptor, animals were pre-treated with mifepristone (25 mg/kg, s.
Pipeline candidates fall under major therapeutic classes such as histamine antagonist and mast cell stabilizers, immune system modulators, glucocorticoid receptor antagonists and Leutocyte elastate inhibitors.
RU38486 reduces the expression of the GH gene by repressing the expression of the GHRHR gene as a consequence of glucocorticoid receptor repression (Ohyama et al.

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