NR3C1

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NR3C1

A gene on chromosome 5q31.3 that encodes a glucocorticoid receptor, which acts as either a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, or as a regulator of other transcription factors.

Molecular pathology
NR3C1 mutation are associated with generalised glucocorticoid resistance.
References in periodicals archive ?
Anti-inflammatory function of ginsenoside Rg1 on alcoholic hepatitis through glucocorticoid receptor related nuclear factor-kappa B pathway.
Messenger RNA expression levels of pregnane X receptor, constitutive androstane receptor, and glucocorticoid receptor in the liver
Visualization of glucocorticoid receptor and mineralocorticoid receptor interactions in living cells with GFP-based fluorescence resonance energy transfer.
rosea Mouse melanoma cells (B16F0) tyrosinase pathway hydrolisate TrkB Salidroside Hippocampus, rats and mice Glucocorticoid receptor Salidroside Hippocampus, rats; Corticotropin-releasing Salidrosid Hippocampus, rats; hormone (CRH) Serotonin receptor 1A R.
Lower methylation of glucocorticoid receptor gene promoter if in peripheral blood of veterans with posttraumatic stress disorder [abstract].
sz]2-adrenergic and glucocorticoid receptor agonist synergism in obstructive airway diseases.
Hippocampal glucocorticoid receptor activation enhances voltagedependent Ca2+ conductances: relevance to brain aging.
Glucocorticoid receptors in major depression: Relevance to pathophysiology and treatment.
Acquired deficit of forebrain glucocorticoid receptor produces depression-like changes in adrenal axis regulation and behavior.
Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk.
The interaction between erythropoiesis and glucocorticoid receptor activity has been inferred by clinically and experimentally (1-6).
2004) reported that increased LG-ABN induces epigenetic changes in the pups at the glucocorticoid receptor promoter in the hippocampus.

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