GRIN2B

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GRIN2B

A gene on chromosome 12p12 that encodes an epsilon subunit of N-methyl-D-aspartate (NMDA) receptors, which belong to the glutamate receptor channel superfamily. NMDA receptors consist of multiple subunits arranged to form a ligand-gated ion channel, which play a key role in long-term potentiation and the plasticity of synapses (central to memory and learning). GRIN2B forms a complex with GRIN1, GRIN3A and PPP2CB; it interacts with HIP1, NETO1, MAGI3 and DAPK1, and with the PDZ domains of INADL and DLG4. It is highly expressed in the fronto-parieto-temporal cortex and hippocampus pyramidal cells.

Molecular pathology
Defects in GRIN2B cause mental retardation autosomal dominant type 8.
References in periodicals archive ?
Subsequent mechanistic studies found that under certain conditions NVP-AAM077 also could inhibit NMDARs containing the GluN2B receptor subunit, suggesting that the selectivity of this compound may not be as strong (Frizelle et al.
GluN2B subunit deletion reveals key role in acute and chronic ethanol sensitivity of glutamate synapses in bed nucleus of the stria terminalis.
GluN2B subunits are components of some NMDA receptors.
If you can't seem to remember things as well as you used to, the problem may well be with the GluN2B subunits in your NMDA receptors.
In recent research, scientists used a genetic therapy in laboratory mice, in which a virus helped carry complementary DNA into appropriate cells and restored some GluN2B subunits.
Within the NMDA receptor are various subunits, and Magnusson said that research keeps pointing back to the GluN2B subunit as one of the most important.
This paper focuses on G1uN2A and GluN2B because these subunits are expressed in forebrain and are intimate participants in excitatory synapse maturation and, in turn, cognitive development.
Like all NMDAR subunits, G1uN2A and GluN2B subunits consist of three basic parts: an extracellular amino region, a series of four transmembrane (TM) segments with connecting extracellular and intracellular loops, and an intracellular carboxy terminus (Fig.
During postnatal development of forebrain synapses, NMDARs transform from containing GluN2B to GluN2A subunits (Fig.
For instance, during early postnatal development, immature hippocampal synapses contain SAP102 and NMDARs with GluN2B (Fig.
One or more of these functional properties that are unique to G1uN2A or GluN2B are likely responsible for changes in activity-dependent synaptic plasticity that occur late in postnatal development during the GluN2B-to-GluN2A switch.
These findings were corroborated in organotypic slices overexpressing GluN2A or GluN2B (Gambrill and Barria, 2011).