focal segmental glomerulosclerosis

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glomerulosclerosis

 [glo-mer″u-lo-sklĕ-ro´sis]
diabetic glomerulosclerosis (intercapillary glomerulosclerosis) a degenerative complication of diabetes mellitus in which there is glomerular mesangial expansion with either diffuse lesions or nodular (Kimmelstiel-Wilson) lesions; symptoms include albuminuria, nephrotic edema, hypertension, renal insufficiency, and retinopathy. The type with nodular lesions is also called Kimmelstiel-Wilson syndrome.
focal segmental glomerulosclerosis focal sclerosing lesions of the renal glomeruli, with proteinuria, hematuria, hypertension, and the nephrotic syndrome; it may be idiopathic or secondary to another condition. Called also focal glomerular sclerosis.

fo·cal seg·men·tal glo·mer·u·lo·scle·ro·sis

segmental collapse of glomerular capillaries with thickened basement membranes and increased mesangial matrix; seen in some glomeruli of patients with nephrotic syndrome or mesangial proliferative glomerulonephritis.

fo·cal seg·men·tal glo·mer·u·lo·scle·ro·sis

(fō'kăl seg-men'tăl glo-mer'yū-lō-skler-ō'sis)
Segmental collapse of glomerular capillaries with thickened basement membranes and increased mesangial matrix; seen in some glomeruli of patients with nephrotic syndrome or mesangial proliferative glomerulonephritis.

focal segmental glomerulosclerosis

An irreversible form of glomerular injury often seen in patients with a history of injection drug use or acquired immunodeficiency syndrome.